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Smoking status: not checked. AREDS2 Formula: what these mean for you changes depending on whether you smoke or used to, and you have not told us. That check was skipped.
Head-to-head evidence comparison — which supplement is right for you?
Aged Garlic Extract vs AREDS2 Formula: Aged Garlic Extract has the stronger overall evidence (7.5 vs 7/10); the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Aged Garlic Extract wins 3 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
9 of 10 studies with measurable effects showed benefit.
Top outcomes
Verdict
Too few graded studies
Top outcomes
600-960mg aged garlic extract — range pending qualified review, and not scoped to a formulation, population, duration or outcome
With meals, Split into 2 doses
Kyolic Aged Garlic Extract (most studied)
One AREDS2 daily regimen, usually split into two servings: vitamin C 500 mg, vitamin E 400 IU, lutein 10 mg, zeaxanthin 2 mg, zinc 80 mg (as zinc oxide) and copper 2 mg (as cupric oxide)
With meals
A product matching the AREDS2 composition exactly: vitamin C 500 mg, vitamin E 400 IU, lutein 10 mg, zeaxanthin 2 mg, zinc 80 mg, copper 2 mg
and 3 more not shown
8-12 weeks
12+ weeks
4-8 weeks
Years — average follow-up was 6.3 years
Years
Long-term
Years
Effect of garlic extract on markers of lipid metabolism and inflammation in coronary artery disease (CAD) patients: A systematic review and meta-analysis
Phytotherapy research : PTR (2023) · Meta analysis
The standardized mean difference with 95% CI was calculated using fixed-effect or random-effect models.
A meta-analysis of randomized, double-blind, placebo-controlled trials for the effects of garlic on serum lipid profiles
Journal of the science of food and agriculture (2012) · Meta analysis
Meta-analysis of 26 randomised, double-blind, placebo-controlled trials of garlic and serum lipids.
A randomized factorial study of the effects of long-term garlic and micronutrient supplementation and of 2-wk antibiotic treatment for Helicobacter pylori infection on serum cholesterol and lipoproteins
The American journal of clinical nutrition (2006) · Rct · n=408
Randomised, double-blind, placebo-controlled factorial trial in 3,411 adults in Linqu County, China, with lipids measured at 3.3 and 7.3 years in 408 of them (34 randomly selected from each of 12 treatment groups).
Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial.
JAMA (2013) · Rct · n=4203
Primary analysis was NULL: lutein/zeaxanthin HR 0.90 (98.7% CI 0.76-1.07, P=.12); DHA+EPA HR 0.97 (0.82-1.16, P=.70); both together HR 0.89 (0.75-1.06, P=.10)
A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8.
Arch Ophthalmol (2001) · Rct · n=3640
Antioxidants plus zinc vs placebo for advanced AMD: OR 0.72 (99% CI 0.52-0.98). Zinc alone OR 0.75 (0.55-1.03); antioxidants alone OR 0.80 (0.59-1.09) — neither significant on its own
Long-term Outcomes of Adding Lutein/Zeaxanthin and ω-3 Fatty Acids to the AREDS Supplements on Age-Related Macular Degeneration Progression: AREDS2 Report 28.
JAMA Ophthalmol (2022) · Cohort · n=3882
10-year lung cancer odds ratio: 1.82 (95% CI 1.06-3.12, P=.02) for beta-carotene assignment vs 1.15 (0.79-1.66, P=.46) for lutein/zeaxanthin
Built from two randomised placebo-controlled trials of aged garlic extract taken on top of blood-pressure medication by people whose hypertension was not controlled. Ried 2013 (PMID 23169470), a dose-response trial in 79 general practice patients over 12 weeks, gave 240, 480 or 960 mg a day: 240 mg did not lower systolic pressure compared with placebo, 480 mg lowered it by 11.8 mmHg (P=0.006), and 960 mg reached a borderline 7.4 mmHg at 8 weeks (P=0.07). Ried 2010 (PMID 20594781), in 50 patients over 12 weeks, found 960 mg a day lowered systolic pressure by 10.2 mmHg (p=0.03) in those starting at 140 mmHg or above, with no significant change in those below 140. The 960 mg point sits no higher than 480 mg because the one trial that compared doses found no extra benefit at the higher dose. 480 mg is the lowest dose with a significant fall. No optimal dose is set, because that trial's arms were small and 960 mg lowered pressure in the second trial, and no ceiling is set on this curve. A 2024 meta-analysis that reported a benefit only above the doses these trials tested has been retracted (PMID 39437887), and no point on this curve rests on it. Aged black garlic extracts dosed by their S-allyl cysteine content (PMID 35276764, 37686723) are a different preparation and are not placed on this axis, and neither is a 2,400 mg trial whose blood pressure result was a secondary before-and-after change in the garlic group (PMID 32349742).
AI-estimated from published studies. Interpret as directional guidance.
Aged Garlic Extract has a higher evidence score (7.5/10 vs 7/10) and wins in 3 of 3 categories.
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.