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Head-to-head evidence comparison — which supplement is right for you?
Aged Garlic Extract wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
13 of 14 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
3 of 4 studies with measurable effects showed benefit.
Top outcomes
600-1200mg aged garlic extract
With meals, Split into 2 doses
Kyolic Aged Garlic Extract (most studied)
1000-2000mg
Morning, With or without food
Calcium alpha-ketoglutarate powder or capsules
8-12 weeks
12+ weeks
4-8 weeks
4-6 months
4-8 weeks
Effects of aged garlic extract on blood pressure in hypertensive patients: A systematic review and meta-analysis of randomized controlled trials
Prostaglandins & other lipid mediators (2024) · Meta analysis · n=584
AGE tea supplementation reduces systolic blood pressure (SBP) (WMD: -4.03; %95CI: -6.87, -1.20; I2: 57.1 %) and diastolic blood pressure (DBP) (WMD: -1.44; 95 % CI= -2.87, -0.02; P = 0.052; I2: 36.8 %; P: 0.105).
Effect of garlic extract on markers of lipid metabolism and inflammation in coronary artery disease (CAD) patients: A systematic review and meta-analysis
Phytotherapy research : PTR (2023) · Meta analysis
The standardized mean difference with 95% CI was calculated using fixed-effect or random-effect models.
A meta-analysis of randomized, double-blind, placebo-controlled trials for the effects of garlic on serum lipid profiles
Journal of the science of food and agriculture (2012) · Meta analysis · n=26
Compared with the placebo groups, serum TC and TG levels in the garlic group were reduced by 0.28 (95% CI, -0.45, -0.11) mmol L⁻¹ (P = 0.001) and 0.13 (95% CI, -0.20, -0.06) mmol L⁻¹ (P < 0.001), respectively.
AKG and the aging epigenome
Nature (2022) · Preclinical
Regulates epigenetic enzymes
Recruitment evaluation of a gerotherapeutic randomized controlled trial testing alpha-ketoglutarate in biologically older, middle-aged adults (ABLE)
Experimental gerontology (2025) · Rct · n=120
Eligibility rates were 80.3 % at pre-screening and 67.3 % at screening, with a consent rate of 66.1 %.
Effects of Multi-Ingredient Pre-Workout Supplement and Caffeine on Bench Press Performance: A Single-Blind Cross-Over Study
Nutrients (2022) · Crossover · n=15
In a cross-over manner, they participated in two sessions where they were blinded to the order of supplementation they were given: either a MIPS including caffeine or caffeine alone.
Meta-analysis shows modest SBP reduction of ~4 mmHg and DBP reduction of ~1.4 mmHg. Effect size is relatively small compared to pharmaceutical interventions. Studies primarily used aged garlic extract forms.
Based on single RCT (n=40) showing prevention of performance decline in track athletes. Effect was prevention of countermovement jump height decrease rather than enhancement. Limited evidence from one small study.
AI-estimated from published studies. Interpret as directional guidance.
Aged Garlic Extract has a higher evidence score (9/10 vs 8.5/10) and wins in 2 of 3 categories.
For healthy aging, Calcium AKG has a higher relevance score (85 vs 58).
No known interactions between Aged Garlic Extract and Calcium AKG have been documented in our database. However, always consult a healthcare provider before combining supplements.