Loading…
We use essential cookies (authentication, your saved goals/stack) by default. With your permission we'll also enable privacy-respecting analytics (Vercel Web Analytics, anonymous load-time metrics) and error-replay diagnostics (Sentry — DOM snapshots only when an error fires) so we can fix bugs faster. Learn more
Head-to-head evidence comparison — which supplement is right for you?
Ashwagandha wins 1 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
3 of 3 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
10 of 10 studies with measurable effects showed benefit.
Top outcomes
500-2500mg daily
Empty stomach for mood/nootropic effects, Pre-workout for pumps, Before bed for neuroprotection
Agmatine Sulfate
300-600mg daily (standardized extract)
Morning for daytime stress, Evening for sleep support
KSM-66 or Sensoril standardized extract
2-4 weeks
1-2 weeks
Ongoing
Acute
2-4 weeks
2-4 weeks
2-4 weeks
First week
Exploring the Cardiovascular Impacts of Agmatine: A Systematic Review
Medical sciences (Basel, Switzerland) (2025) · Systematic review
The effects exerted by AG depend on the dose and route of administration, as well as on the receptors involved and the pathophysiological pathway used.
Role of Inflammatory Mechanisms in Major Depressive Disorder: From Etiology to Potential Pharmacological Targets
Cells (2024) · Systematic review
Together, neuroinflammation and gut dysbiosis induce alterations in tryptophan metabolism, culminating in decreased serotonin synthesis, impairments in neuroplasticity-related mechanisms, and glutamate-mediated excitotoxicity.
Role of agmatine in neurodegenerative diseases and epilepsy
Frontiers in bioscience (Elite edition) (2014) · Systematic review
Agmatine, a cationic polyamine synthesized after decarboxylation of L-arginine by the enzyme arginine decarboxylase, is an endogenous neuromodulator that emerges as a potential agent to manage diverse central nervous system (CNS) disorders.
Effects of Ashwagandha (Withania Somnifera) on stress and anxiety: A systematic review and meta-analysis
Journal of the American Nutrition Association (2024) · Meta analysis · n=873
Significant reduction in HAM-A anxiety scores (p=0.0007)
Effects of Withania somnifera Extract in Chronically Stressed Adults: A Randomized Controlled Trial
Nutrients (2024) · Rct · n=131
Our findings demonstrate the stress-reduction capabilities of this well-characterized aqueous extract of WS (root and leaf) at the low dose of 125 mg/day, in a dose-dependent manner, via the modulation of the HPA axis.
Plant-derived nootropics and human cognition: A systematic review
Critical reviews in food science and nutrition (2023) · Systematic review
Bacopa monnieri improves language, learning and memory.
Based on single pilot study (n=11) showing 46% pain reduction. Very limited evidence with small sample size. GI discomfort may occur at higher doses. Individual variation noted in study.
Based on meta-analysis showing significant HAM-A score reduction (p=0.0007) and RCT evidence at 125mg dose. High heterogeneity (I2=98%) in pooled analysis suggests variable response. Extract standardization affects bioavailability.
AI-estimated from published studies. Interpret as directional guidance.
Ashwagandha has a higher evidence score (7.5/10 vs 7/10) and wins in 1 of 3 categories.
For reduce anxiety & stress, Ashwagandha has a higher relevance score (95 vs 55).
No known interactions between Agmatine and Ashwagandha have been documented in our database. However, always consult a healthcare provider before combining supplements.