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Head-to-head evidence comparison — which supplement is right for you?
Andrographis vs Chlorella: Chlorella has the stronger overall evidence (6.5 vs 7/10); they're alternatives for support immune system — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Chlorella wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
3 of 4 studies with measurable effects showed benefit.
Top outcomes
Verdict
Too few graded studies
Top outcomes
Shared outcomes (1)
Outcomes where both Andrographis and Chlorella have evidence — compare verdict strength side-by-side.
400mg extract (standardized to 10-30% andrographolides), 3x daily for acute use
At first sign of cold symptoms, With meals
Standardized extract (10-30% andrographolides)
3-10g daily
Before meals for detox, With food if GI sensitive, Away from medications (may bind)
Broken cell wall chlorella powder or tablets
2-5 days
2-5 days
2-5 days
4-8 weeks
4-8 weeks
8-12 weeks
First 1-2 weeks
Herbal Medicines for the Treatment of Active Ulcerative Colitis: A Systematic Review and Meta-Analysis
Nutrients (2024) · Meta analysis
In pooled analyses, when compared with placebo, clinical response rates were significantly higher for Indigo naturalis (IN) (RR 3.70, 95% CI 1.97-6.95), but not for Curcuma longa (CL) (RR 1.60, 95% CI 0.99-2.58) or Andrographis paniculata (AP) (RR 0.95, 95% CI 0.71-1.26).
Safety of Andrographis paniculata: A systematic review and meta-analysis
Pharmacoepidemiology and drug safety (2021) · Meta analysis
Incidence of serious AEs was very rare with the pooled incidence (95% CI) from RCTs of 0.02 per 1000 patients (0.0-0.5).
A double-blind, randomized, placebo-controlled study to assess the efficacy of Andrographis paniculata standardized extract (ParActin®) on pain reduction in subjects with knee osteoarthritis
Phytotherapy research : PTR (2019) · Rct · n=103
Patients treated with 300 or 600 mg/day of ParActin® showed a significant reduction in pain at days 28, 56, and 84 compared with a placebo group.
Identifying immunostimulatory herbal supplements that may flare autoimmune skin diseases: a systematic scoping review
Lupus science & medicine (2025) · Review
Scoping review screening 11,819 articles, of which 469 studies met inclusion criteria, identified 227 herbal supplements with immunostimulatory properties.
Effect of supplementation with Chlorella vulgaris on lipid profile in adults: A systematic review and dose-response meta-analysis of randomized controlled trials
Complementary therapies in medicine (2022) · Meta analysis · n=539
Meta-analysis of 10 RCTs with 539 adults (264 given Chlorella vulgaris, 275 controls).
Dietary Interventions in the Management of Fibromyalgia: A Systematic Review and Best-Evidence Synthesis
Nutrients (2020) · Systematic review
It is estimated to have a worldwide prevalence of 1.78%, with a predominance in females.
Two placebo-controlled trials of the same standardised extract (KalmCold, also sold as AP-Bio). At 200 mg a day, 223 adults with an uncomplicated upper respiratory infection had lower overall symptom scores than placebo by day 5 (PMID 20092985). In a 300-person trial of 200 or 400 mg a day for 7 days, both doses lowered symptom scores on day 3 by the same amount, with no difference on days 5 and 7, and no participant reported adverse physical symptoms (PMID 36842634). 400 mg was no better than 200 mg, so the curve is flat and no optimal dose is given. The respiratory infection meta-analysis (PMID 28783743) reports symptom benefits but no doses, so it is not plotted.
At 1.5 g a day for 8 weeks, a double-blind trial in 84 adults with type 2 diabetes found no change in blood lipids (PMID 33532874). At 5 g a day for 4 weeks, two double-blind trials found an effect: in 63 mildly hypercholesterolaemic adults total cholesterol changed -1.6% versus 0.03% on placebo (PMID 24920270), and in 34 adults eating three eggs a day LDL-C rose 1.7% versus 14.3% on placebo (PMID 27177615). At 15 g a day for 14 days, total and LDL cholesterol fell in 80 healthy adults (PMID 37049486), but uric acid rose and iron and selenium status fell. The meta-analyses disagree on dose: one found reductions at doses above 4 g a day (PMID 29037431), another found the LDL-C reduction at doses up to 1,500 mg and not above (PMID 35331862). No trial compared doses, so the curve is flat above 5 g and no minimum, optimal or safe ceiling is set.
AI-estimated from published studies. Interpret as directional guidance.
Chlorella has a higher evidence score (6.5/10 vs 7/10) and wins in 2 of 3 categories.
For support immune system, Andrographis has a higher relevance score (90 vs 60).
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.