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Head-to-head evidence comparison — which supplement is right for you?
Apigenin and Passionflower are closely matched across evidence, studies, and safety.
Verdict
Probably helps
3 of 5 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
4 of 4 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (2)
Outcomes where both Apigenin and Passionflower have evidence — compare verdict strength side-by-side.
50mg before bed
30-60 minutes before bed
Apigenin extract capsules
250-500mg extract (or 2g dried herb)
For anxiety: as needed, For sleep: 30-60 minutes before bed
Standardized extract capsules
30-60 minutes
30-60 minutes
N/A
30 min - 2 hours
30-60 minutes
30-60 minutes
Efficacy and potential pharmacological mechanism of Astragalus-Salvia miltiorrhiza combination in diabetic nephropathy: integrating meta-analysis, network pharmacology, molecular docking, and experimental validation
Renal failure (2025) · Meta analysis · n=1443
Meanwhile, when the treatment duration exceeds 12 weeks, AS demonstrated a significant reduction in fasting blood glucose levels, indicating a time-dependent effect.
Levodopa and Plant-Derived Bioactive Compounds in Parkinson's Disease: Mechanisms, Efficacy, and Future Perspectives
CNS neuroscience & therapeutics (2025) · Systematic review
Although levodopa is indispensable for the symptomatic management of PD, emerging evidence supports the integration of plant-derived bioactive compounds as adjunct therapies with disease-modifying potential.
Dietary Flavonoids and the Risk of Colorectal Cancer: An Updated Meta-Analysis of Epidemiological Studies
Nutrients (2018) · Meta analysis · n=12
High intake of dietary flavonols, flavones and anthocyanidins may decrease the risk of colorectal cancer; the pooled odds ratio (OR) for the highest intake compared with the lowest was 0.70 (0.54⁻0.90), 0.79 (0.83⁻0.99) and 0.78 (0.64⁻0.95), respectively.
Herbal Remedies and Their Possible Effect on the GABAergic System and Sleep
Nutrients (2021) · Systematic review
Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter that plays a major role in controlling different vigilance states.
Passiflora incarnata in Neuropsychiatric Disorders-A Systematic Review
Nutrients (2020) · Systematic review
Passiflora incarnata may be helpful in treating some symptoms in neuropsychiatric patients.
Herbal medicine for depression and anxiety: A systematic review with assessment of potential psycho-oncologic relevance
Phytotherapy research : PTR (2018) · Systematic review
Overall, 45% of studies reported positive findings with fewer adverse effects compared with conventional medications.
Based on preclinical studies showing neuroinflammation inhibition and lung injury models. Human clinical data lacking. Effects may vary significantly based on bioavailability and individual response.
Based on meta-analysis of 198 subjects noting insufficient RCT data for definitive conclusions. Effectiveness limited by small sample sizes and study quality limitations. Drowsiness is primary dose-limiting side effect.
AI-estimated from published studies. Interpret as directional guidance.
Both Apigenin and Passionflower are closely matched — the best choice depends on your specific health goals.
For reduce anxiety & stress, Passionflower has a higher relevance score (85 vs 70).
No known interactions between Apigenin and Passionflower have been documented in our database. However, always consult a healthcare provider before combining supplements.