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Passiflora incarnata
GABA-modulating vine that rivals benzodiazepines for generalized anxiety in trials — with fewer side effects and no dependence risk.
What the evidence says
Passionflower appears to help in 4 of 4 studies with measurable effects — the evidence leans clearly favourable.
Most evidence is from high-quality meta-analyses and randomised trials published 2001–2025 with a typical study size of 110 participants.
Based on 30 studies · 2 meta-analyses · 5 RCTs · 3,651 total participants
Confidence
HighWhat the studies found
By outcome
Passionflower has an evidence score of 8/10 — strong evidence based on 30 indexed studies, including 2 meta-analyses. GABA-modulating vine that rivals benzodiazepines for generalized anxiety in trials — with fewer side effects and no dependence risk.
The commonly studied dose of Passionflower is 250-500mg extract (or 2g dried herb). Research points to an estimated optimal dose around 500mg extract, with a minimum effective dose near 250mg extract. Individual response varies — start low and adjust.
The best time to take Passionflower is before bed. Taking it with food is preferred. Passiflora incarnata contains chrysin and other flavonoids that modulate GABA-A receptors, promoting anxiolysis and sedation.
Last reviewed May 2026 · evidence from 36 studies · how we score
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
Passionflower is a climbing vine with beautiful flowers that has been used traditionally for anxiety and sleep. Research suggests it works through GABA modulation and may be as effective as some benzodiazepines for anxiety, but with fewer side effects. Often used for generalized anxiety and sleep difficulties.
Increases GABA activity for calming effects
May mildly inhibit monoamine oxidase
How Passionflower works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
250-500mg extract (or 2g dried herb)
Can be taken without food
| Form | Type |
|---|---|
| 💊Standardized extract capsules | Recommended |
| 🍵Tea | Alternative |
| 💧Tincture | Alternative |
| 💊Dried herb | Alternative |
Tea is traditional and effective for sleep. Extracts are more potent and consistent.
Minimum: 1 weeks
Optimal: 4 weeks
Cycling: Not required
Note: Can be taken with or without food. Tea form works well before bed.
You can get passionflower from these foods and drinks. Doses are typical per-serving estimates — actual content varies by brand, brew, cooking, etc.
250 mg per cup
1 cup from 1 tsp dried aerial parts.
Based on meta-analysis of 198 subjects noting insufficient RCT data for definitive conclusions. Effectiveness limited by small sample sizes and study quality limitations. Drowsiness is primary dose-limiting side effect.
Significant reduction in anxiety symptoms
Better sleep quality and duration
May cause sleepiness during day
Avoid — may stimulate uterine contractions
Limited data; not recommended
Additive sedative effects
Potential interaction due to weak MAOI activity
May have mild anticoagulant effects — may affect platelet aggregation or vitamin K-dependent clotting factors, altering anticoagulant efficacy
Tip: Avoid driving; take before bed
Tip: Reduce dose
Tip: Take with food
Passionflower is generally well-tolerated and considered safe for most healthy adults at recommended doses. The most commonly reported side effects are drowsiness, dizziness, nausea. Use caution if any of these apply to you: Pregnancy (may stimulate uterine contractions); Before surgery (stop 2 weeks prior).
Kava
Probably helpsKavalactones produce anxiolytic and muscle-relaxing effects comparable to prescription anti-anxiety medications in clinical trials.
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