We use essential cookies (authentication, your saved goals/stack) by default. With your permission we'll also enable privacy-respecting analytics (Vercel Web Analytics, anonymous load-time metrics) and error-replay diagnostics (Sentry — DOM snapshots only when an error fires) so we can fix bugs faster. Learn more
Apigenin
Chamomile flavonoid that binds GABA receptors to promote sleep and relaxation — the active compound behind chamomile's calming effects.
What the evidence says
Apigenin helped in about half (3/5) of the studies that measured an effect — promising, but not unanimous.
Most evidence is from high-quality meta-analyses and randomised trials published 1995–2026 with a typical study size of 57 participants.
Based on 32 studies · 7 meta-analyses · 10 RCTs · 107,553 total participants
Confidence
HighWhat the studies found
By outcome
Apigenin has an evidence score of 8/10 — strong evidence based on 32 indexed studies, including 8 meta-analyses. Chamomile flavonoid that binds GABA receptors to promote sleep and relaxation — the active compound behind chamomile's calming effects.
The commonly studied dose of Apigenin is 50mg before bed. Research points to an estimated optimal dose around 100mg, with a minimum effective dose near 50mg. Individual response varies — start low and adjust.
The best time to take Apigenin is before bed. Taking it with food is preferred. Apigenin acts as a positive allosteric modulator of GABA-A receptors and inhibits CD38, supporting NAD+ levels.
Last reviewed May 2026 · evidence from 36 studies · how we score
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
Apigenin is a flavonoid found in chamomile, parsley, and other plants. It binds to GABA receptors and has anxiolytic (anti-anxiety) and sleep-promoting effects. While direct human studies are limited, its mechanism is well-understood and it's a key reason chamomile has been used for sleep for centuries.
Binds to GABA receptors for calming effects
May preserve NAD+ levels (longevity pathway)
Reduces inflammatory markers
How Apigenin works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
50mg before bed
Can be taken without food
| Form | Type |
|---|---|
| 💊Apigenin extract capsules | Recommended |
| 💊Chamomile extract (standardized) | Alternative |
| 🍵Chamomile tea (lower dose) | Alternative |
Pure apigenin provides consistent dosing. Chamomile extract should be standardized to apigenin content. Chamomile tea provides variable, lower doses (~3-10mg per cup).
Minimum: 1 weeks
Optimal: 4 weeks
Cycling: Not required
Note: Take before bed for sleep. Can be combined with other sleep supplements like magnesium and L-theanine.
Based on preclinical studies showing neuroinflammation inhibition and lung injury models. Human clinical data lacking. Effects may vary significantly based on bioavailability and individual response.
Calm, relaxed feeling without heavy sedation
Helps transition to sleep more easily
Effects are gentle; not a strong sedative
Chamomile tea is common during pregnancy; concentrated supplements less studied
May cross-react; avoid or use caution
May have additive sedative effects
Chamomile family may have mild anticoagulant effects — may affect platelet aggregation or vitamin K-dependent clotting factors, altering anticoagulant efficacy
Tip: Take only before bed
Tip: Avoid if allergic to ragweed/chamomile
Apigenin is generally well-tolerated and considered safe for most healthy adults at recommended doses. The most commonly reported side effects are drowsiness, allergic reaction. Use caution if any of these apply to you: Allergy to chamomile or ragweed family.
Omega-3
Probably helpsEssential fatty acids critical for brain health, mood regulation, and reducing inflammation throughout the body.
Tap node to isolate • Pinch to zoom • Tap edge for research