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Head-to-head evidence comparison — which supplement is right for you?
Avanafil (Stendra) vs Vardenafil (Levitra): Avanafil (Stendra) has the stronger overall evidence (3.6 vs 3.6/10); take care combining them — there's a flagged interaction. Take the 60-second quiz for a pick tailored to your goals.
Avanafil (Stendra) wins 1 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Mostly mechanism / observational
Top outcomes
Shared outcomes (2)
Outcomes where both Avanafil (Stendra) and Vardenafil (Levitra) have evidence — compare verdict strength side-by-side.
Approved on-demand ED dosing is 50-200 mg taken roughly 15-30 minutes before activity (100 mg typical start; range 50-200 mg). It can be taken with or without food. Any use is clinician-directed; this is not a supplement regimen.
any
Oral tablet (avanafil)
Approved on-demand ED dosing is 5-20 mg taken ~30-60 minutes before activity (10 mg typical start for the film-coated tablet); the orodispersible Staxyn tablet is 10 mg. Any use is clinician-directed and prescription-only; this is not a supplement regimen.
any
Oral film-coated tablet (vardenafil HCl)
and 1 more not shown
Additive hypotension, dizziness and syncope; a raised risk of priapism, and of a dangerous fall in blood pressure if a nitrate is ever needed acutely.
Never combine. There is no additive benefit — switching between PDE5 inhibitors means stopping one before starting the other, and any change should go through the prescriber.
Acute (~15-30 min onset)
Acute (per dose)
Acute (per dose)
Acute (per dose)
Acute (~30-60 min onset)
Weeks
Acute (per dose)
With interacting drugs / at-risk patients
A randomized, double-blind, placebo-controlled evaluation of the safety and efficacy of avanafil in subjects with erectile dysfunction.
The Journal of Sexual Medicine (2012) · Rct
REVIVE: 12-week phase-3 double-blind, placebo-controlled RCT of on-demand avanafil (50, 100, 200 mg) in men with erectile dysfunction
Avanafil for the treatment of erectile dysfunction: a multicenter, randomized, double-blind study in men with diabetes mellitus.
Mayo Clinic Proceedings (2012) · Rct
REVIVE-Diabetes: 12-week multicenter, randomized, double-blind RCT of avanafil in men with ED and diabetes mellitus
Avanafil for male erectile dysfunction: a systematic review and meta-analysis.
Asian Journal of Andrology (2014) · Meta analysis
Systematic review and meta-analysis pooling randomized placebo-controlled avanafil trials
The efficacy and tolerability of vardenafil, a new, oral, selective phosphodiesterase type 5 inhibitor, in patients with erectile dysfunction: the first at-home clinical trial.
International Journal of Impotence Research (2001) · Rct
Multicentre, randomized, double-blind, placebo-controlled at-home trial in 601 men with mild-to-severe erectile dysfunction
Vardenafil, a new phosphodiesterase type 5 inhibitor, in the treatment of erectile dysfunction in men with diabetes: a multicenter double-blind placebo-controlled fixed-dose study.
Diabetes Care (2003) · Rct
Prospective multicenter double-blind placebo-controlled fixed-dose RCT in men with diabetes and erectile dysfunction
Safety and efficacy of vardenafil for the treatment of men with erectile dysfunction after radical retropubic prostatectomy.
The Journal of Urology (2003) · Rct
Randomized, double-blind, placebo-controlled trial in men with erectile dysfunction after radical retropubic prostatectomy
Avanafil (Stendra) has a higher evidence score (3.6/10 vs 3.6/10) and wins in 1 of 3 categories.
Both Avanafil (Stendra) and Vardenafil (Levitra) score equally (55) for libido & male vitality.
Caution: Additive hypotension, dizziness and syncope; a raised risk of priapism, and of a dangerous fall in blood pressure if a nitrate is ever needed acutely. Never combine. There is no additive benefit — switching between PDE5 inhibitors means stopping one before starting the other, and any change should go through the prescriber. Always consult a healthcare provider before combining these supplements.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.