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Head-to-head evidence comparison — which supplement is right for you?
ASU and Devil's Claw are closely matched across evidence, studies, and safety.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Mostly mechanism / observational
Top outcomes
Shared outcomes (1)
Outcomes where both ASU and Devil's Claw have evidence — compare verdict strength side-by-side.
300mg ASU daily (standardized avocado:soybean unsaponifiables)
with-meals
Standardized ASU (300mg)
Standardized extract providing 50-100mg harpagoside daily (≈600-2400mg extract)
with-meals
Harpagoside-standardized extract
1-3 months
1-3 months
Throughout use
2-8 weeks
2-8 weeks
Days
Efficacy and safety of avocado-soybean unsaponifiables for the treatment of hip and knee osteoarthritis: A systematic review and meta-analysis of randomized placebo-controlled trials.
Int J Rheum Dis (2019) · Meta analysis
A subanalysis according to the type of OA showed that ASU significantly decreased both VAS and Lequesne index in knee OA (WMD: -17.36, 95% CI: -25.91, -8.82; P < .0001 and WMD: -2.33, 95% CI: -2.88, -1.78; P < .00001, respectively) but not in hip OA.
Symptomatic efficacy of avocado-soybean unsaponifiables (ASU) in osteoarthritis (OA) patients: a meta-analysis of randomized controlled trials.
Osteoarthritis Cartilage (2008) · Meta analysis
Four trials were included, with 664 OA patients with either hip (41.4%) or knee (58.6%) OA allocated to either 300 mg ASU (336) or placebo (328).
Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis.
Br J Sports Med (2018) · Meta analysis
Of 20 supplements investigated in 69 eligible studies, avocado soybean unsaponifiables revealed statistically significant improvements on pain, but were of unclear clinical importance.
Harpgophytum procumbens for osteoarthritis and low back pain: a systematic review.
BMC complementary and alternative medicine (2004) · Systematic review
Twelve trials reviewed across OA and low-back pain
Herbal Medicine for Low Back Pain: A Cochrane Review.
Spine (2016) · Systematic review
14 RCTs (2050 participants) of herbal medicines for low-back pain
Herbal medicine for low-back pain.
The Cochrane database of systematic reviews (2014) · Systematic review
Devil's claw standardized to 50-100mg harpagoside may beat placebo short-term
Both ASU and Devil's Claw are closely matched — the best choice depends on your specific health goals.
For joint health & mobility, Devil's Claw has a higher relevance score (65 vs 60).
No known interactions between ASU and Devil's Claw have been documented in our database. However, always consult a healthcare provider before combining supplements.