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Head-to-head evidence comparison — which supplement is right for you?
B. coagulans vs L. acidophilus: B. coagulans has the stronger overall evidence (5 vs 5/10); they're alternatives for improve digestion — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
B. coagulans wins 1 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
1-2 billion CFU (spores) daily. The IBS-D and gas/bloating trials used 2 x 10^9 CFU/day of MTCC 5856 (LactoSpore); the GBI-30 6086 (BC30) studies used 1 x 10^9 CFU/day.
any
Tablet or capsule delivering a named strain — MTCC 5856 (LactoSpore) for IBS, GBI-30 6086 (BC30) for the exercise and amino-acid claims
1-100 billion CFU (10^9 to 10^11) per serving — the range FDA reviewed without objection for L. acidophilus DDS-1 in foods generally (GRAS Notice GRN 871); La-14 was noticed at 1 billion CFU per 250 g serving (GRN 502)
any
A product naming its strain (e.g. NCFM, DDS-1, La-14, La-5)
4-12 weeks
4 weeks
n/a
n/a
Weeks
Weeks
Course of antibiotics
Outcome-Specific Efficacy of Different Probiotic Strains and Mixtures in Irritable Bowel Syndrome: A Systematic Review and Network Meta-Analysis.
Nutrients (2023) · Meta analysis
B. coagulans MTCC 5856 (SUCRA 96.9%) and B. coagulans Unique IS2 (SUCRA 92.6%) were among the most effective probiotics for improving abdominal pain
Probiotics and synbiotics in chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
Clin Nutr (2022) · Meta analysis
Probiotics increased stool frequency overall (SMD 0.71, 95% CI 0.37-1.04, P<0.00001), with Bifidobacterium lactis driving the effect
The effects of Bacillus coagulans MTCC 5856 on functional gas and bloating in adults: A randomized, double-blind, placebo-controlled study.
Medicine (Baltimore) (2023) · Rct · n=70
GSRS indigestion score fell from 8.91 to 3.06 in the probiotic group versus 9.42 to 8.43 on placebo; between-group P<0.001
Lactobacillus acidophilus DDS-1 and Bifidobacterium lactis UABla-12 Improve Abdominal Pain Severity and Symptomology in Irritable Bowel Syndrome: Randomized Controlled Trial.
Nutrients (2020) · Rct
Multicentre randomised controlled trial in irritable bowel syndrome (PubMed publication types: Randomized Controlled Trial, Multicenter Study)
The effects of the DDS-1 strain of lactobacillus on symptomatic relief for lactose intolerance - a randomized, double-blind, placebo-controlled, crossover clinical trial.
Nutr J (2016) · Crossover
Randomised, double-blind, placebo-controlled crossover trial (PubMed publication types: Randomized Controlled Trial)
Lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in older inpatients (PLACIDE): a randomised, double-blind, placebo-controlled, multicentre trial.
Lancet (2013) · Rct
Randomised, double-blind, placebo-controlled multicentre trial in inpatients aged 65 and over (PubMed publication types: Randomized Controlled Trial, Multicenter Study)
B. coagulans has a higher evidence score (5/10 vs 5/10) and wins in 1 of 3 categories.
For improve digestion, B. coagulans has a higher relevance score (58 vs 55).
No known interactions between B. coagulans and L. acidophilus have been documented in our database. However, always consult a healthcare provider before combining supplements.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.