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Head-to-head evidence comparison — which supplement is right for you?
B. coagulans vs L. acidophilus: B. coagulans has the stronger overall evidence (5 vs 5/10); they're alternatives for improve digestion — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
B. coagulans wins 1 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Too few graded studies
Top outcomes
Verdict
Too few graded studies
Top outcomes
Shared outcomes (1)
Outcomes where both B. coagulans and L. acidophilus have evidence — compare verdict strength side-by-side.
1-2 billion CFU (spores) daily. The IBS-D and gas/bloating trials used 2 x 10^9 CFU/day of MTCC 5856 (LactoSpore); the GBI-30 6086 (BC30) studies used 1 x 10^9 CFU/day.
Any time of day
Tablet or capsule delivering a named strain — MTCC 5856 (LactoSpore) for IBS, GBI-30 6086 (BC30) for the exercise and amino-acid claims
1-100 billion CFU (10^9 to 10^11) per serving — the range FDA reviewed without objection for L. acidophilus DDS-1 in foods generally (GRAS Notice GRN 871); La-14 was noticed at 1 billion CFU per 250 g serving (GRN 502) (the one cited trial that states a dose used 10 billion CFU a day)
Any time of day
A product naming its strain (e.g. NCFM, DDS-1, La-14, La-5)
4-12 weeks
4 weeks
n/a
n/a
Weeks
Weeks
Course of antibiotics
Outcome-Specific Efficacy of Different Probiotic Strains and Mixtures in Irritable Bowel Syndrome: A Systematic Review and Network Meta-Analysis.
Nutrients (2023) · Meta analysis
B. coagulans MTCC 5856 (SUCRA 96.9%) and B. coagulans Unique IS2 (SUCRA 92.6%) were among the most effective probiotics for improving abdominal pain
Probiotics and synbiotics in chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
Clin Nutr (2022) · Meta analysis
Probiotics increased stool frequency overall (SMD 0.71, 95% CI 0.37-1.04, P<0.00001), with Bifidobacterium lactis driving the effect
The effects of Bacillus coagulans MTCC 5856 on functional gas and bloating in adults: A randomized, double-blind, placebo-controlled study.
Medicine (Baltimore) (2023) · Rct · n=70
GSRS indigestion score fell from 8.91 to 3.06 in the probiotic group versus 9.42 to 8.43 on placebo; between-group P<0.001
Lactobacillus acidophilus DDS-1 and Bifidobacterium lactis UABla-12 Improve Abdominal Pain Severity and Symptomology in Irritable Bowel Syndrome: Randomized Controlled Trial.
Nutrients (2020) · Rct · n=330
Randomised, double-blind, placebo-controlled multicentre trial in 330 adults with IBS (Rome IV), allocated 1:1:1 to placebo, L. acidophilus DDS-1 alone or B. lactis UABla-12 alone, each at 1 × 10^10 CFU/day for six weeks
The effects of the DDS-1 strain of lactobacillus on symptomatic relief for lactose intolerance - a randomized, double-blind, placebo-controlled, crossover clinical trial.
Nutr J (2016) · Crossover
Randomised, double-blind, placebo-controlled crossover trial in adults with self-reported lactose intolerance confirmed by a lactose challenge: 4 weeks of DDS-1 or maltodextrin placebo once daily, with a 2-week washout
Lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in older inpatients (PLACIDE): a randomised, double-blind, placebo-controlled, multicentre trial.
Lancet (2013) · Rct · n=2981
Randomised, double-blind, placebo-controlled multicentre trial in 2,981 inpatients aged 65 and over taking antibiotics, given a multistrain preparation of lactobacilli and bifidobacteria (6 × 10^10 organisms per day for 21 days) or placebo
B. coagulans has a higher evidence score (5/10 vs 5/10) and wins in 1 of 3 categories.
For improve digestion, B. coagulans has a higher relevance score (58 vs 55).
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.