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Head-to-head evidence comparison — which supplement is right for you?
Red Yeast Rice wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
4 of 5 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
15 of 16 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Bergamot and Red Yeast Rice have evidence — compare verdict strength side-by-side.
500-1000mg bergamot polyphenolic fraction (BPF)
With meals, Once or twice daily
Bergamot polyphenolic fraction (BPF) — Bergamonte is well-studied
1200-2400mg providing 10mg monacolin K
Evening (cholesterol synthesis peaks at night)
Standardized extract with verified monacolin K content
4-12 weeks
4-12 weeks
8-12 weeks
8-12 weeks
8-12 weeks
A network meta-analysis on the comparative effect of nutraceuticals on lipid profile in adults
Pharmacological research (2022) · Meta analysis · n=13062
Evidence for bergamot effect was based on relatively small study group and may require further investigations.
Randomized, Double-Blind, Placebo-Controlled Trial to Test the Effects of a Nutraceutical Combination Monacolin K-Free on the Lipid and Inflammatory Profile of Subjects with Hypercholesterolemia
Nutrients (2022) · Rct · n=118
Compared to the placebo, at 6 and 12 weeks, NC did not significantly reduce total cholesterol (p = 0.083), LDL cholesterol (p = 0.150), and triglycerides (p = 0.822).
Effect of bergamot on lipid profile in humans: A systematic review
Critical reviews in food science and nutrition (2020) · Systematic review · n=442
Although statins can reduce LDLc by 50-60%, less than 20% of patients with high risk of CVD achieve LDL targets.
Efficacy and Safety of Armolipid Plus(®): An Updated PRISMA Compliant Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials
Nutrients (2021) · Meta analysis · n=1050
Armolipid Plus® was well tolerated.
Safety and Efficacy of the Consumption of the Nutraceutical "Red Yeast Rice Extract" for the Reduction of Hypercholesterolemia in Humans: A Systematic Review and Meta-Analysis
Nutrients (2024) · Meta analysis
The consumption of RYR extract by people with hypercholesterolemia was associated with statistically significant reduction in total cholesterol and LDL-C, whereas it was not associated with an increase in life-threatening side effects.
Impact of Berberine or Berberine Combination Products on Lipoprotein, Triglyceride and Biological Safety Marker Concentrations in Patients with Hyperlipidemia: A Systematic Review and Meta-Analysis
Journal of dietary supplements (2024) · Meta analysis · n=4838
Products with berberine alone had less robust effects on TC (MD -12.08 mg/dL [95%CI: -21.79 to -2.37]), LDL (MD -9.26 mg/dL [95%CI: -20.31 to 1.78]), and HDL (MD 1.38 mg/dL [95%CI: -1.27 to 4.03]) but TG effects were similar (MD -17.40 mg/dL [95%CI: -32.57 to -2.23]).
Based on systematic review showing 75% of studies had significant effects, but meta-analysis noted small study groups requiring further investigation. One RCT showed no significant reduction at 6-12 weeks.
Based on RCT showing 16.77% reduction with 3mg and 26.46% reduction with 10mg monacolin K. Conservative effectiveness scaling due to limited dose-response data and variable study quality noted in meta-analyses.
AI-estimated from published studies. Interpret as directional guidance.
Red Yeast Rice has a higher evidence score (7.8/10 vs 6.5/10) and wins in 2 of 3 categories.
Both Bergamot and Red Yeast Rice score equally (90) for reduce inflammation.
No known interactions between Bergamot and Red Yeast Rice have been documented in our database. However, always consult a healthcare provider before combining supplements.