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Head-to-head evidence comparison — which supplement is right for you?
Caffeine wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
22 of 25 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
3 of 3 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Caffeine and PQQ have evidence — compare verdict strength side-by-side.
100-200mg
Morning, 30-60 minutes before exercise
Pill/capsule for precise dosing
10-20mg
Morning with breakfast
BioPQQ capsules (most studied form)
15-45 minutes
30-60 minutes
30-60 minutes
30-60 minutes
4-8 weeks
4-8 weeks
4-8 weeks
Effect of Acute Caffeine Intake on the Fat Oxidation Rate during Exercise: A Systematic Review and Meta-Analysis
Nutrients (2020) · Meta analysis · n=2020
A subsequent meta-analysis was performed using the random effects model to calculate the standardized mean difference (SMD).
The effects of caffeine intake on weight loss: a systematic review and dos-response meta-analysis of randomized controlled trials
Critical reviews in food science and nutrition (2019) · Meta analysis · n=606
Thirteen RCTs with 606 participants were included in the meta-analyses.
Effect of Caffeine and Nitrates Combination on Exercise Performance, Heart Rate and Oxygen Uptake: A Systematic Review and Meta-Analysis
Nutrients (2024) · Meta analysis · n=95
The meta-analysis revealed that caffeine and nitrates supplementation (CAF+nitrates) did not enhance performance in time trials (TTs) over the CAF alone (g = -0.06; 95% CI = -0.46 to 0.35; p = 0.78) or nitrates alone (g = 0.29; 95% CI = -0.12 to 0.70; p = 0.17).
Mini-review: Functions and Action Mechanisms of PQQ in Osteoporosis and Neuro Injury
Current stem cell research & therapy (2020) · Systematic review
Owing to the inherent properties of PQQ as an antioxidant and redox modulator in various systems.
Prolonging healthy aging: Longevity vitamins and proteins
Proceedings of the National Academy of Sciences of the United States of America (2018) · Systematic review
Impairment of the function of longevity proteins results in an insidious acceleration of the risk of diseases associated with aging.
Recent progress in studies on the health benefits of pyrroloquinoline quinone
Bioscience, biotechnology, and biochemistry (2016) · Systematic review
Although PQQ is not currently classified as a vitamin, PQQ has been implicated as an important nutrient in mammals.
Based on multiple meta-analyses showing 3-6mg/kg optimal dosing. Performance benefits plateau around 200-300mg with increased jitteriness at higher doses.
Based on RCT showing 9-12% TAC increase and isoprostane reduction. Limited to one small study (n=20). Conservative estimates given small sample size and single outcome measure.
AI-estimated from published studies. Interpret as directional guidance.
Caffeine has a higher evidence score (9.5/10 vs 8/10) and wins in 2 of 3 categories.
For boost daily energy, Caffeine has a higher relevance score (98 vs 75).
No known interactions between Caffeine and PQQ have been documented in our database. However, always consult a healthcare provider before combining supplements.