Head-to-head evidence comparison — which supplement is right for you?
Caffeine wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
100-200mg
Morning, 30-60 minutes before exercise
Pill/capsule for precise dosing
10-20mg
Morning with breakfast
BioPQQ capsules (most studied form)
15-45 minutes
30-60 minutes
30-60 minutes
30-60 minutes
4-8 weeks
4-8 weeks
4-8 weeks
Effect of Acute Caffeine Intake on the Fat Oxidation Rate during Exercise: A Systematic Review and Meta-Analysis
Nutrients (2020) · Meta analysis · n=2020
A subsequent meta-analysis was performed using the random effects model to calculate the standardized mean difference (SMD).
The effects of caffeine intake on weight loss: a systematic review and dos-response meta-analysis of randomized controlled trials
Critical reviews in food science and nutrition (2019) · Meta analysis · n=606
Thirteen RCTs with 606 participants were included in the meta-analyses.
Early versus Late Caffeine Therapy Administration in Preterm Neonates: An Updated Systematic Review and Meta-Analysis
Neonatology (2024) · Meta analysis · n=122579
A total of 122,579 patients from 11 studies were included, 2 were randomized controlled trials (RCTs), and 63.9% of the neonates received early caffeine administration.
Mini-review: Functions and Action Mechanisms of PQQ in Osteoporosis and Neuro Injury
Current stem cell research & therapy (2020) · Systematic review
Owing to the inherent properties of PQQ as an antioxidant and redox modulator in various systems.
Prolonging healthy aging: Longevity vitamins and proteins
Proceedings of the National Academy of Sciences of the United States of America (2018) · Systematic review
Impairment of the function of longevity proteins results in an insidious acceleration of the risk of diseases associated with aging.
Recent progress in studies on the health benefits of pyrroloquinoline quinone
Bioscience, biotechnology, and biochemistry (2016) · Systematic review
Although PQQ is not currently classified as a vitamin, PQQ has been implicated as an important nutrient in mammals.
Caffeine has a higher evidence score (9.5/10 vs 8/10) and wins in 2 of 3 categories.
For boost daily energy, Caffeine has a higher relevance score (98 vs 75).
No known interactions between Caffeine and PQQ have been documented in our database. However, always consult a healthcare provider before combining supplements.