Pyrroloquinoline Quinone
Unique compound that promotes the growth of new mitochondria, supporting cellular energy and brain health.
PQQ is a compound found in soil and certain foods that supports mitochondrial biogenesis — the creation of new mitochondria. This makes it unique among supplements. Research shows benefits for cognitive function, sleep quality, and energy. Often paired with CoQ10 for comprehensive mitochondrial support.
Stimulates creation of new mitochondria
Powerful antioxidant through electron cycling
May support nerve growth
How PQQ works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
10-20mg
Take with food
| Form | Type |
|---|---|
| 💊BioPQQ capsules (most studied form) | Recommended |
| 💊Generic PQQ disodium salt | Alternative |
BioPQQ is the patented, most studied form. Low doses are effective.
Minimum: 4 weeks
Optimal: 8 weeks
Cycling: Not required
Note: Taking with food may improve absorption. Morning dosing aligns with mitochondrial energy needs.
Better memory and mental clarity
More sustained energy
Improved sleep quality
Insufficient data; avoid
Generally safe with medications
Tip: Start with lower dose
Tip: Take in morning
PQQ creates new mitochondria; CoQ10 powers them
Comprehensive mitochondrial support
Both support mitochondrial function
Multi-target cellular energy support
PQQ creates new mitochondria; urolithin A removes damaged ones
Complete mitochondrial turnover support
PQQ stimulates mitochondrial biogenesis through CREB and PGC-1α; NR supports the NAD+ substrate for the same pathways — both target mitochondrial quantity and quality.
Synergistic mitochondrial biogenesis and enhanced cellular energy production
Top studies from 35+ peer-reviewed papers
Wen H et al. • Current stem cell research & therapy (2020)
“It provides new ideas in the study of osteoporosis and neuro injury.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.”
Ames BN • Proceedings of the National Academy of Sciences of the United States of America (2018)
“Because nutrient deficiencies are highly prevalent in the United States (and elsewhere), appropriate supplementation and/or an improved diet could reduce much of the consequent risk of chronic disease and premature aging.”
Akagawa M et al. • Bioscience, biotechnology, and biochemistry (2016)
“Additionally, we provide an update of its basic pharmacokinetics and safety information in oral ingestion.”
Misra HS et al. • Journal of biosciences (2012)
“This review discusses different findings suggesting the versatility in PQQ functions and provides the most plausible intellectual basis to the ubiquitous roles of this compound in a large number of biological processes, as a nutrient and a perspective vitamin.”
Ulpathakumbura S et al. • Ageing research reviews (2026)
“Despite supporting preliminary data and patented formulations, strong scientific evidence encouraging the synergistic anti-aging potential of PQQ and NMN/NR remains limited, highlighting the need f...”
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