Loading…
We use essential cookies (authentication, your saved goals/stack) by default. With your permission we'll also enable privacy-respecting analytics (Vercel Web Analytics, anonymous load-time metrics) and error-replay diagnostics (Sentry — DOM snapshots only when an error fires) so we can fix bugs faster. Learn more
Head-to-head evidence comparison — which supplement is right for you?
Caffeine wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
22 of 25 studies with measurable effects showed benefit.
Top outcomes
Verdict
Mostly mechanism / observational
Top outcomes
Shared outcomes (1)
Outcomes where both Caffeine and Tyrosine have evidence — compare verdict strength side-by-side.
100-200mg
Morning, 30-60 minutes before exercise
Pill/capsule for precise dosing
500-2000mg
30-60 minutes before stressful activity, On empty stomach for best absorption
L-Tyrosine powder or capsules
15-45 minutes
30-60 minutes
30-60 minutes
30-60 minutes
30-60 minutes
30-60 minutes
30-60 minutes
Effect of Acute Caffeine Intake on the Fat Oxidation Rate during Exercise: A Systematic Review and Meta-Analysis
Nutrients (2020) · Meta analysis · n=2020
A subsequent meta-analysis was performed using the random effects model to calculate the standardized mean difference (SMD).
The effects of caffeine intake on weight loss: a systematic review and dos-response meta-analysis of randomized controlled trials
Critical reviews in food science and nutrition (2019) · Meta analysis · n=606
Thirteen RCTs with 606 participants were included in the meta-analyses.
Effect of Caffeine and Nitrates Combination on Exercise Performance, Heart Rate and Oxygen Uptake: A Systematic Review and Meta-Analysis
Nutrients (2024) · Meta analysis · n=95
The meta-analysis revealed that caffeine and nitrates supplementation (CAF+nitrates) did not enhance performance in time trials (TTs) over the CAF alone (g = -0.06; 95% CI = -0.46 to 0.35; p = 0.78) or nitrates alone (g = 0.29; 95% CI = -0.12 to 0.70; p = 0.17).
Tyrosine promotes cognitive flexibility: evidence from proactive vs. reactive control during task switching performance
Neuropsychologia (2015) · Rct · n=22
Tyrosine supplementation improved task switching performance under demanding conditions
Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands: A review
Journal of Psychiatric Research (2015) · Review
Converging evidence for cognitive enhancement under demanding conditions
Based on multiple meta-analyses showing 3-6mg/kg optimal dosing. Performance benefits plateau around 200-300mg with increased jitteriness at higher doses.
Based on single meta-analysis of 56 participants showing significantly higher blood tyrosine concentrations with supplementation. Clinical significance of elevated blood tyrosine levels for cognitive outcomes remains unclear. Most claimed cognitive effects lack direct study support in the provided evidence.
AI-estimated from published studies. Interpret as directional guidance.
Caffeine has a higher evidence score (9.5/10 vs 7/10) and wins in 2 of 3 categories.
For boost daily energy, Caffeine has a higher relevance score (98 vs 60).
No known interactions between Caffeine and Tyrosine have been documented in our database. However, always consult a healthcare provider before combining supplements.