L-Tyrosine / N-Acetyl L-Tyrosine (NALT)
Amino acid precursor to dopamine and norepinephrine, supporting focus and mental performance under stress.
L-Tyrosine is an amino acid that serves as a precursor to dopamine, norepinephrine, and epinephrine. It's most effective for maintaining cognitive performance during stress, sleep deprivation, or demanding tasks. Benefits are most pronounced when catecholamine levels are depleted by stress or fatigue.
Provides building blocks for dopamine and norepinephrine
Replenishes neurotransmitters depleted by stress
How Tyrosine works β from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta β pathways are being refined and expanded.
500-2000mg
Can be taken without food
| Form | Type |
|---|---|
| πL-Tyrosine powder or capsules | Recommended |
| πN-Acetyl L-Tyrosine (NALT) β more soluble but may be less effective | Alternative |
L-Tyrosine is better studied. NALT has better solubility but may not convert to tyrosine as efficiently.
Minimum: 1 days
Optimal: days
Cycling: Best used as needed rather than daily. Chronic high-dose use may downregulate receptors. Use for demanding periods, then take breaks.
Note: Take on empty stomach as it competes with other amino acids for absorption. NALT may be taken with food. Most effective when used acutely before demanding tasks.
Better cognitive performance during demanding tasks
Better short-term memory during stress
Less cognitive decline from acute stressors
Insufficient data; likely safe at dietary levels
Consult doctor as tyrosine affects thyroid function
May cause dangerous increase in catecholamines
Tyrosine is a precursor to thyroid hormones; may affect levels
May compete for absorption and affect efficacy
Tip: Reduce dose
Tip: Take with small amount of food
Tip: Lower dose; don't combine with stimulants
Both support alertness through different mechanisms
Enhanced mental performance; start with lower doses of each
B vitamins are cofactors in catecholamine synthesis
Supports the conversion of tyrosine to neurotransmitters
Both affect dopamine β may be excessive together
Use one or the other, not both
Top studies from 39+ peer-reviewed papers
Ma Z et al. β’ BMJ (Clinical research ed.) (2025)
βIn patients with EGFR-mutated NSCLC, first and third generation EGFR tyrosine kinase inhibitors, as well as combination therapies with antiangiogenesis, were associated with increased risks of cardiovascular adverse events.β
Zhao Y et al. β’ The Lancet. Oncology (2024)
βFor individuals with advanced EGFR-mutated NSCLC who progressed on EGFR-TKIs, ICI-antiangio-chemo was identified as the optimal treatment option.β
Buchrits S et al. β’ Annals of hematology (2025)
βThis meta-analysis examined the effects of Tyrosine.β
Zong S et al. β’ Frontiers in immunology (2025)
βSeven therapies showed better efficacy than TACE alone for particular patients with intermediate-stage HCC.β
Zhang W et al. β’ BMC pulmonary medicine (2024)
βOur study concluded that combination regimens based on third-generation TKIs (osimertinib plus ramucirumab, osimertinib plus chemotherapy, osimertinib plus bevacizumab, amivantamab plus lazertinib and aumolertinib plus apatinib) could be the new and clinically preferable first-line, standard of care for EGFR-mutated advanced non-small cell lung cancer.β
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