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Head-to-head evidence comparison — which supplement is right for you?
Citrulline Malate wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
3 of 4 studies with measurable effects showed benefit.
Top outcomes
Verdict
Probably helps
6 of 10 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (2)
Outcomes where both Citrulline Malate and Sodium Bicarbonate have evidence — compare verdict strength side-by-side.
6-8g citrulline malate pre-workout
30-60 minutes before exercise, Empty stomach or with light carbs
Citrulline Malate 2:1 powder
0.2-0.3g per kg bodyweight (14-21g for 70kg person)
60-180 minutes before exercise, Split into multiple doses
Pharmaceutical-grade sodium bicarbonate powder or capsules
Acute (within session)
Acute
24-48 hours
Acute
Acute (1-3 hours)
Acute
Acute Effect of Citrulline Malate on Repetition Performance During Strength Training: A Systematic Review and Meta-Analysis
International Journal of Sport Nutrition and Exercise Metabolism (2021) · Meta analysis · n=198
Small ergogenic effect (SMD=0.196)
Impact of Chronic Nitrate and Citrulline Malate Supplementation on Performance and Recovery in Spanish Professional Female Soccer Players: A Randomized Controlled Trial
Nutrients (2025) · Rct · n=60
Plasma NO3- concentrations significantly increased from baseline in the NIT + CM group and remained elevated 24 h after the final dose, confirming sustained systemic exposure.
Effects of Acute Citrulline Malate Supplementation on CrossFit(®) Exercise Performance: A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Study
Nutrients (2024) · Crossover · n=21
The results indicated no significant difference in the number of rounds completed between the CM and placebo conditions (13.5 ± 5.2 vs. 13.8 ± 6.7 rounds, respectively; p = 0.587).
Sodium Bicarbonate Treatment and Clinical Outcomes in Chronic Kidney Disease with Metabolic Acidosis: A Meta-Analysis
Clinical journal of the American Society of Nephrology : CJASN (2024) · Meta analysis · n=2037
Fourteen RCTs comprising 2037 patients demonstrated that sodium bicarbonate supplementation significantly improved eGFR (standardized mean difference [SMD], 0.33; 95% confidence interval [CI], 0.03 to 0.63; P = 0.03).
Nutritional Ergogenic Aids in Cycling: A Systematic Review
Nutrients (2024) · Systematic review · n=701
However, no statistically significant effects were identified for the remaining supplements, whether administered individually or in combination.
Effects of Different Dietary Supplements on Swimming Performance: A Systematic Review and Network Meta-Analysis
Nutrients (2024) · Meta analysis
L-arginine (Arg) demonstrated superior performance to the placebo (SMD = -1.66, 95% CI [-2.92, -0.44]), emerging as the most effective intervention for reducing 100 swimming time (SUCRA = 89.5%).
Meta-analysis showed small effect (SMD=0.196) with ~3 additional reps. Several individual studies showed mixed results including null findings. Effect appears inconsistent across different exercise modalities.
Based on meta-analyses showing performance improvements in combat sports and cycling. GI distress is dose-limiting factor. Effects primarily observed in events lasting 1-7 minutes. Individual variation in tolerance is high.
AI-estimated from published studies. Interpret as directional guidance.
Citrulline Malate has a higher evidence score (6/10 vs 7.5/10) and wins in 2 of 3 categories.
For improve endurance, Sodium Bicarbonate has a higher relevance score (90 vs 75).
No known interactions between Citrulline Malate and Sodium Bicarbonate have been documented in our database. However, always consult a healthcare provider before combining supplements.