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Head-to-head evidence comparison — which supplement is right for you?
CoQ10 wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
17 of 21 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
3 of 3 studies with measurable effects showed benefit.
Top outcomes
100-300mg daily
With fatty meal
Ubiquinol (reduced form)
10-20mg
Morning with breakfast
BioPQQ capsules (most studied form)
Enhanced mitochondrial quantity and quality
TAKE TOGETHER for optimal mitochondrial health.
4-12 weeks
8-12 weeks
4-8 weeks
2-8 weeks
4-8 weeks
4-8 weeks
4-8 weeks
Efficacy and Safety of Coenzyme Q10 Supplementation in the Treatment of Polycystic Ovary Syndrome: a Systematic Review and Meta-analysis
Reproductive sciences (Thousand Oaks, Calif.) (2023) · Meta analysis · n=1021
Only one RCT reported adverse events, and they found that patients had no adverse effects or symptoms following supplementation.
Coenzyme Q10 for heart failure
The Cochrane database of systematic reviews (2021) · Meta analysis · n=1573
Coenzyme Q10 probably reduces the risk of all-cause mortality more than control (RR 0.58, 95% CI 0.35 to 0.95; 1 study, 420 participants; number needed to treat for an additional beneficial outcome (NNTB) 13.3; moderate-quality evidence).
Antioxidants for female subfertility
The Cochrane database of systematic reviews (2017) · Meta analysis · n=6510
This suggests that among subfertile women with an expected clinical pregnancy rate of 22%, the rate among women using antioxidants would be between 27% and 33%.
Mini-review: Functions and Action Mechanisms of PQQ in Osteoporosis and Neuro Injury
Current stem cell research & therapy (2020) · Systematic review
Owing to the inherent properties of PQQ as an antioxidant and redox modulator in various systems.
Prolonging healthy aging: Longevity vitamins and proteins
Proceedings of the National Academy of Sciences of the United States of America (2018) · Systematic review
Impairment of the function of longevity proteins results in an insidious acceleration of the risk of diseases associated with aging.
Recent progress in studies on the health benefits of pyrroloquinoline quinone
Bioscience, biotechnology, and biochemistry (2016) · Systematic review
Although PQQ is not currently classified as a vitamin, PQQ has been implicated as an important nutrient in mammals.
Based on heart failure meta-analysis (n=1573) showing mortality reduction. Effectiveness conservative due to single primary study (n=420). Take with food to reduce GI upset. Ubiquinol forms may have better absorption.
Based on RCT showing 9-12% TAC increase and isoprostane reduction. Limited to one small study (n=20). Conservative estimates given small sample size and single outcome measure.
AI-estimated from published studies. Interpret as directional guidance.
CoQ10 has a higher evidence score (8/10 vs 4.5/10) and wins in 2 of 3 categories.
For boost daily energy, CoQ10 has a higher relevance score (75 vs 30).
CoQ10 and PQQ may work well together: Enhanced mitochondrial quantity and quality TAKE TOGETHER for optimal mitochondrial health.