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Head-to-head evidence comparison — which supplement is right for you?
Cranberry Extract vs Vitamin B6: they're closely matched on evidence (6 vs 7/10); they're alternatives for support immune system — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Cranberry Extract and Vitamin B6 are closely matched across evidence, studies, and safety.
Verdict
Probably helps
6 of 9 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
10 of 13 studies with measurable effects showed benefit.
Top outcomes
36mg PACs (proanthocyanidins) or 400-500mg extract standardized to PAC content
Morning and evening, With or without food
Extract standardized to 36mg PACs (A-type)
25-100mg daily
Morning with food, Can take with other B vitamins
P-5-P (Pyridoxal-5-Phosphate)
Ongoing
2-4 weeks
1-2 cycles
Months of high doses
Cranberries for preventing urinary tract infections
Cochrane Database of Systematic Reviews (2023) · Systematic review · n=8857
Fifth update of the Cochrane review; 50 included studies with 8857 randomised participants.
Consumption of cranberry as adjuvant therapy for urinary tract infections in susceptible populations: A systematic review and meta-analysis with trial sequential analysis
PloS one (2021) · Meta analysis · n=3979
Meta-analysis of 23 trials with 3979 participants.
Supplementation with Highly Standardized Cranberry Extract Phytosome Achieved the Modulation of Urinary Tract Infection Episodes in Diabetic Postmenopausal Women Taking SGLT-2 Inhibitors: A RCT Study
Nutrients (2024) · Rct
Considering UTI episodes, during the six-month supplementation period, an increase of 1.321 (95% CI: -0.322; 2.9650) was observed in the placebo group, while it remained at a steady value of 0.393 (95% CI: -4.230; 5.016) in the supplemented group.
Dosage exploration of combined B-vitamin supplementation in stroke prevention: a meta-analysis and systematic review
The American journal of clinical nutrition (2024) · Meta analysis · n=76664
In areas without and with partial folic acid fortification, combined B-vitamin supplementation significantly reduced the risk of stroke by 34% [RR: 0.66; 95% confidence interval (CI): 0.50, 0.86] and 11% (RR: 0.89; 95% CI: 0.79, 1.00), respectively.
Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life
The Cochrane database of systematic reviews (2018) · Meta analysis · n=83000
We found that giving B vitamin supplements to cognitively healthy adults, mainly in their 60s and 70s, probably has little or no effect on global cognitive function at any time point up to 5 years (SMD values from -0.03 to 0.06) and may also have no effect at 5-10 years (SMD -0.01).
Drug Efficacy in the Treatment of Antipsychotic-Induced Akathisia: A Systematic Review and Network Meta-Analysis
JAMA network open (2024) · Meta analysis · n=492
No association between effect sizes and psychotic severity was found.
Based on multiple RCTs showing UTI reduction in women. Effect size varies significantly between studies (15-73% reduction). Most effective for recurrent UTI prevention. PAC-standardized extracts preferred over juice forms for consistent dosing and reduced GI effects.
Based on systematic review of nutritional interventions for PMS psychological symptoms. Evidence quality limited by study heterogeneity and need for more consistent protocols.
AI-estimated from published studies. Interpret as directional guidance.
Both Cranberry Extract and Vitamin B6 are closely matched — the best choice depends on your specific health goals.
For support immune system, Cranberry Extract has a higher relevance score (85 vs 65).
No known interactions between Cranberry Extract and Vitamin B6 have been documented in our database. However, always consult a healthcare provider before combining supplements.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.