Loading…
We use essential cookies (authentication, your saved goals/stack) by default. With your permission we'll also enable privacy-respecting analytics (Vercel Web Analytics, anonymous load-time metrics) and error-replay diagnostics (Sentry — DOM snapshots only when an error fires) so we can fix bugs faster. Learn more
Head-to-head evidence comparison — which supplement is right for you?
Echinacea wins 1 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Probably helps
6 of 11 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
13 of 15 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Echinacea and Saccharomyces Boulardii have evidence — compare verdict strength side-by-side.
300-500mg extract 3x daily at first symptoms, OR 2.5ml tincture 3x daily
At first sign of symptoms, Multiple times daily during illness
Standardized extract (4% echinacosides or standardized alkylamides)
250-500mg (5-10 billion CFU) daily
With or without food, At least 2 hours away from antifungals
Capsules (lyophilized)
With continuous use
When taken at onset
During use
1-3 days
1-2 weeks
Identifying immunostimulatory herbal supplements that may flare autoimmune skin diseases: a systematic scoping review
Lupus science & medicine (2025) · Systematic review · n=469
We identified 227 herbal supplements with immunostimulatory properties, of which 15 were most strongly supported by the evidence.
Echinacea Supplementation Does Not Impact Aerobic Capacity and Erythropoiesis in Athletes: A Meta-Analysis
Nutrients (2024) · Meta analysis · n=107
There was also no statistically significant change in erythropoietin (effect size -0.29, p = 0.05, 95% CI -0.75-0.17, I2 = 67%) or maximal oxygen uptake (effect size -0.20, p = 0.95, 95% CI -0.60-0.21, I2 = 0%).
Select Dietary Supplement Ingredients for Preserving and Protecting the Immune System in Healthy Individuals: A Systematic Review
Nutrients (2022) · Systematic review
Immune health products represent approximately 10% of all US dietary supplement sales.
Efficacy and safety of Saccharomyces boulardii as an adjuvant therapy for the eradication of Helicobacter pylori: a meta-analysis
Frontiers in cellular and infection microbiology (2025) · Meta analysis · n=5036
S. boulardii supplementation in traditional eradication therapy significantly improves the H. pylori eradication rate and reduces the total adverse effects and incidence of diarrhea, bloating, constipation, and nausea.
Probiotics for treating acute infectious diarrhoea
The Cochrane database of systematic reviews (2020) · Meta analysis · n=12127
Effect size was similar in the sensitivity analysis and marked heterogeneity persisted.
The use of probiotics and prebiotics in decolonizing pathogenic bacteria from the gut; a systematic review and meta-analysis of clinical outcomes
Gut microbes (2024) · Meta analysis · n=2871
This review aims to analyze available evidence from human-controlled trials to determine the effect size of probiotic interventions in decolonizing AMR pathogenic bacteria from the gut.
Based on meta-analyses showing modest SMD of -0.19. Significant heterogeneity between products tested. Evidence stronger for E. purpurea aerial parts preparations.
Based on multiple meta-analyses showing 1.1-1.6 day reduction in diarrhea duration. Effect size appears to plateau at standard therapeutic doses. Limited data on doses above 20 billion CFU.
AI-estimated from published studies. Interpret as directional guidance.
Echinacea has a higher evidence score (9/10 vs 9/10) and wins in 1 of 3 categories.
For reduce inflammation, Saccharomyces Boulardii has a higher relevance score (90 vs 52).
No known interactions between Echinacea and Saccharomyces Boulardii have been documented in our database. However, always consult a healthcare provider before combining supplements.