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Head-to-head evidence comparison — which supplement is right for you?
Enclomiphene vs Vitex: Vitex has the stronger overall evidence (7 vs 4.2/10); they're alternatives for testosterone & cortisol balance — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Vitex wins 3 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Likely helps
12 of 13 studies with measurable effects showed benefit.
Top outcomes
Investigational / off-label — no FDA-approved dose exists. Trials studied oral enclomiphene citrate at 6.25-25 mg once daily (12.5 mg and 25 mg were the Phase-3 doses). Compounded enclomiphene is used off-label under a clinician at similar doses, but quality and content are not regulated.
any
Oral enclomiphene citrate (compounded; investigational — never marketed as an approved drug)
20-40mg extract (standardized to 0.5% agnuside)
Morning, Consistently at same time daily
Standardized extract (0.5% agnuside or 0.6% aucubin)
Weeks to a few months
Within 3-6 months
N/A
N/A
1-3 cycles
2-3 cycles
1-2 cycles
Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement.
BJU Int (2016) · Rct
Two parallel randomized, double-blind, double-dummy, placebo-controlled, multicentre Phase-3 trials (ZA-304/ZA-305) of 12.5 mg and 25 mg enclomiphene vs testosterone gel (AndroGel 1.62%) in overweight men 18-60 with secondary hypogonadism
Enclomiphene citrate stimulates testosterone production while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone.
Fertil Steril (2014) · Rct
Phase-2 randomized trial of oral enclomiphene citrate vs 1% topical testosterone gel in men with secondary hypogonadism (NCT01270841)
Oral enclomiphene citrate stimulates the endogenous production of testosterone and sperm counts in men with low testosterone: comparison with testosterone gel.
J Sex Med (2013) · Open label · n=12
Proof-of-principle randomized, open-label, active-control, two-center Phase-2B study in 12 men with secondary hypogonadism previously on topical testosterone
Vitex agnus-castus in premenstrual syndrome: A meta-analysis of double-blind randomised controlled trials
Complementary Therapies in Medicine (2019) · Meta analysis · n=1878
Vitex significantly reduced overall PMS symptom scores vs placebo
Herbal medicine for depression and anxiety: A systematic review with assessment of potential psycho-oncologic relevance
Phytotherapy research : PTR (2018) · Systematic review
Overall, 45% of studies reported positive findings with fewer adverse effects compared with conventional medications.
A Critical Approach to Evaluating Clinical Efficacy, Adverse Events and Drug Interactions of Herbal Remedies
Phytotherapy research : PTR (2016) · Review
A critical evaluation of the clinical data regarding the adverse effects has shown that herbal remedies are generally better tolerated than synthetic medications.
Based on meta-analysis of RCTs showing large effect size. Most effective for irritability, mood swings, and breast tenderness. Standardized extracts (Ze 440, BNO 1095) had strongest evidence. High heterogeneity noted between studies.
AI-estimated from published studies. Interpret as directional guidance.
Vitex has a higher evidence score (7/10 vs 4.2/10) and wins in 3 of 3 categories.
For testosterone & cortisol balance, Vitex has a higher relevance score (92 vs 62).
No known interactions between Enclomiphene and Vitex have been documented in our database. However, always consult a healthcare provider before combining supplements.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.