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Head-to-head evidence comparison — which supplement is right for you?
Flibanserin vs Maca: Maca has the stronger overall evidence (5.5 vs 4.5/10); they're alternatives for libido & sexual wellness — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Maca wins 3 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Likely helps
3 of 3 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Flibanserin and Maca have evidence — compare verdict strength side-by-side.
100 mg once daily at bedtime — every night, not before sexual activity. Prescription only. Discontinue at 8 weeks if there has been no improvement in symptoms.
before-bed
Addyi 100 mg oral tablet, once daily at bedtime
1500-3000mg
Morning or early afternoon, With food
Gelatinized maca powder (easier to digest)
and 2 more not shown
Measured at 24 weeks in the pivotal trials
24 weeks
Across the whole trial programme
From the first doses; bedtime dosing is used to shift them out of waking hours
6-12 weeks
4-8 weeks
4-8 weeks
Efficacy and Safety of Flibanserin for the Treatment of Hypoactive Sexual Desire Disorder in Women: A Systematic Review and Meta-analysis.
JAMA Internal Medicine (2016) · Meta analysis · n=5914
Systematic review and meta-analysis of 5 published and 3 unpublished randomized trials including 5,914 premenopausal and postmenopausal women
Role of flibanserin in managing hypoactive sexual desire disorder in women: A systematic review and meta-analysis.
Medicine (Baltimore) (2024) · Meta analysis · n=7906
Systematic review and meta-analysis of 8 randomized controlled trials involving 7,906 women with hypoactive sexual desire disorder
Treatment of hypoactive sexual desire disorder in premenopausal women: efficacy of flibanserin in the DAISY study.
The Journal of Sexual Medicine (2012) · Rct · n=1581
DAISY: 24-week randomized trial in North American premenopausal women with HSDD (mean age 35), assigned to flibanserin 25 mg twice daily (n=396), 50 mg twice daily (n=392), 100 mg once daily at bedtime (n=395), or placebo (n=398)
Effects of Maca (Lepidium meyenii Walp.) on Physical Performance in Animals and Humans: A Systematic Review and Meta-Analysis
Nutrients (2024) · Meta analysis
They revealed a large effect for all outcomes (SMD: FST = 2.26, RRT = 6.26, GST = 5.23, LA = -1.01, and BLA = -1.70).
A review of the study of active components and their pharmacology value in Lepidium meyenii (Maca)
Phytotherapy research : PTR (2021) · Review
Additionally, the research on the change of active components in Maca at different growth stages by MS will be beneficial to full utilization of active components in Maca and other natural resources.
Enhancement of Interferon-γ Secretion by Lepidium meyenii Extract Supplementation After Exhaustive Endurance Exercise in Healthy Men: A Double-blind, Placebo-controlled Trial
International journal of medical sciences (2025) · Rct · n=20
Regarding the main time effect, the number of lymphocytes in all participants was significantly lower at 2 and 4 hours after exercise than before supplementation.
Based on meta-analysis showing large effect sizes for physical performance outcomes. Effects may vary significantly between raw and gelatinized forms. Limited human studies with small sample sizes.
AI-estimated from published studies. Interpret as directional guidance.
Maca has a higher evidence score (5.5/10 vs 4.5/10) and wins in 3 of 3 categories.
For libido & sexual wellness, Maca has a higher relevance score (80 vs 55).
No known interactions between Flibanserin and Maca have been documented in our database. However, always consult a healthcare provider before combining supplements.
CoQ10, zinc, selenium, carnitine modestly help sperm parameters — but live-birth evidence is weak.
Hot flashes, bone, sleep, muscle — the basics that hold up vs the phytoestrogen hype.
The transition years (40s): cycle changes, mood, sleep, brain fog — foundations, vitex, and starting muscle work early.
Mostly hype unless you’re deficient — what has modest evidence vs what doesn’t, and when to see a doctor.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.