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Head-to-head evidence comparison — which supplement is right for you?
Caffeine and Maca are closely matched across evidence, studies, and safety.
Verdict
Likely helps
22 of 25 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
4 of 4 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Caffeine and Maca have evidence — compare verdict strength side-by-side.
100-200mg
Morning, 30-60 minutes before exercise
Pill/capsule for precise dosing
1500-3000mg
Morning or early afternoon, With food
Gelatinized maca powder (easier to digest)
15-45 minutes
30-60 minutes
30-60 minutes
30-60 minutes
2-4 weeks
4-8 weeks
4-8 weeks
Effect of Acute Caffeine Intake on the Fat Oxidation Rate during Exercise: A Systematic Review and Meta-Analysis
Nutrients (2020) · Meta analysis · n=2020
A subsequent meta-analysis was performed using the random effects model to calculate the standardized mean difference (SMD).
The effects of caffeine intake on weight loss: a systematic review and dos-response meta-analysis of randomized controlled trials
Critical reviews in food science and nutrition (2019) · Meta analysis · n=606
Thirteen RCTs with 606 participants were included in the meta-analyses.
Effect of Caffeine and Nitrates Combination on Exercise Performance, Heart Rate and Oxygen Uptake: A Systematic Review and Meta-Analysis
Nutrients (2024) · Meta analysis · n=95
The meta-analysis revealed that caffeine and nitrates supplementation (CAF+nitrates) did not enhance performance in time trials (TTs) over the CAF alone (g = -0.06; 95% CI = -0.46 to 0.35; p = 0.78) or nitrates alone (g = 0.29; 95% CI = -0.12 to 0.70; p = 0.17).
Effects of Maca (Lepidium meyenii Walp.) on Physical Performance in Animals and Humans: A Systematic Review and Meta-Analysis
Nutrients (2024) · Meta analysis
They revealed a large effect for all outcomes (SMD: FST = 2.26, RRT = 6.26, GST = 5.23, LA = -1.01, and BLA = -1.70).
A review of the study of active components and their pharmacology value in Lepidium meyenii (Maca)
Phytotherapy research : PTR (2021) · Systematic review
Additionally, the research on the change of active components in Maca at different growth stages by MS will be beneficial to full utilization of active components in Maca and other natural resources.
Enhancement of Interferon-γ Secretion by Lepidium meyenii Extract Supplementation After Exhaustive Endurance Exercise in Healthy Men: A Double-blind, Placebo-controlled Trial
International journal of medical sciences (2025) · Rct · n=20
Regarding the main time effect, the number of lymphocytes in all participants was significantly lower at 2 and 4 hours after exercise than before supplementation.
Based on multiple meta-analyses showing 3-6mg/kg optimal dosing. Performance benefits plateau around 200-300mg with increased jitteriness at higher doses.
Based on meta-analysis showing large effect sizes for physical performance outcomes. Effects may vary significantly between raw and gelatinized forms. Limited human studies with small sample sizes.
AI-estimated from published studies. Interpret as directional guidance.
Both Caffeine and Maca are closely matched — the best choice depends on your specific health goals.
For boost daily energy, Caffeine has a higher relevance score (98 vs 70).
No known interactions between Caffeine and Maca have been documented in our database. However, always consult a healthcare provider before combining supplements.