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Head-to-head evidence comparison — which supplement is right for you?
Iodine wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
8 of 10 studies with measurable effects showed benefit.
Top outcomes
Verdict
Mixed evidence
4 of 12 studies with measurable effects showed benefit.
Top outcomes
100-300mg (standardized to 95% OPCs)
With meals
Standardized extract (95% OPCs or proanthocyanidins)
150-300mcg for maintenance; higher only if deficient under supervision
Any time with food
Potassium iodide (most common and studied)
4-8 weeks
8-12 weeks
8-12 weeks
4-12 weeks
4-8 weeks
Phlebotonics for venous insufficiency
The Cochrane database of systematic reviews (2020) · Meta analysis · n=7690
Pooled data suggest that phlebotonics probably increase adverse events slightly, compared to placebo (RR 1.14, 95% CI 1.02 to 1.27; 37 studies; 5789 participants; moderate-certainty evidence).
Does the Grape Products Intake has an Effect on Body Weight in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Current drug targets (2024) · Meta analysis · n=1284
The outcomes have revealed grape products intake to significantly decrease body weight (p = 0.001) and body mass index (p = 0.004) in obese participants, and also, a greater effect was observed when grape seed extract was used.
Low Dose Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts Lowers LDL Cholesterol in Patients with Mild Dyslipidemia: A Multicenter, Randomized Controlled Trial
Nutrients (2023) · Rct · n=105
LDL-C decreased by 26.46% on average (p < 0.001) during treatment with 10 mg of monacolin and by 16.77% on average during treatment with 3 mg of monacolin (p < 0.001).
Maternal Iodine Status and Birth Outcomes: A Systematic Literature Review and Meta-Analysis
Nutrients (2023) · Meta analysis · n=42269
Birth weight was similar between UIC ≥ 150 μg/L and <150 μg/L (difference = 30 g, 95% CI −22 to 83, p = 0.3, n = 13, I2 = 89%) with no evidence of linear trend (4 g per 50 μg/L, −3 to 10, p = 0.2, n = 12, I2 = 80%).
Iodine fortification of foods and condiments, other than salt, for preventing iodine deficiency disorders
The Cochrane database of systematic reviews (2019) · Meta analysis · n=4317
This is equivalent to an increase of 38.32 µg/L (95% CI 24.03 to 52.61 µg/L).
Systematic review and meta-analysis of iodine nutrition in modern vegan and vegetarian diets
The British journal of nutrition (2023) · Meta analysis · n=4421
Vegan diets had the poorest iodine intake (17·3 µg/d) and were strongly associated with lower iodine intake (P = < 0·001) compared with omnivorous diets.
Based on meta-analysis showing mean reductions of -6.07 mmHg systolic and -2.82 mmHg diastolic. Effects more pronounced in younger adults and those with metabolic conditions. Dizziness may indicate blood pressure reduction.
Based on meta-analyses showing urinary iodine concentration increases with supplementation. Effects only meaningful in iodine-deficient populations. Excessive intake (>300mcg) may increase thyroid cancer risk. Most studies used potassium iodide; kelp-derived forms have variable bioavailability.
AI-estimated from published studies. Interpret as directional guidance.
Iodine has a higher evidence score (8.5/10 vs 6/10) and wins in 2 of 3 categories.
No known interactions between Grape Seed Extract and Iodine have been documented in our database. However, always consult a healthcare provider before combining supplements.