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Head-to-head evidence comparison — which supplement is right for you?
Horse Chestnut vs Red Vine Leaf Extract: Horse Chestnut has the stronger overall evidence (7 vs 5.4/10); they're alternatives for leg circulation & vein health — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Horse Chestnut wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Too few graded studies
Top outcomes
Verdict
Too few graded studies
Top outcomes
Shared outcomes (1)
Outcomes where both Horse Chestnut and Red Vine Leaf Extract have evidence — compare verdict strength side-by-side.
300mg standardized extract twice daily (providing ~50mg aescin per dose; ~100mg aescin/day). A typical label dose, no cited trial of oral horse chestnut states its dose.
With meals
Aescin-standardized, enteric-coated seed extract
360 mg standardised red vine leaf extract once daily, up to 720 mg once daily. These are the doses given in the placebo-controlled trials, for 6 to 12 weeks.
Any time of day
Standardised red vine leaf dry extract, 360 to 720 mg
2-12 weeks
2-8 weeks
Days
6-12 weeks
6-12 weeks
Days
Horse chestnut seed extract for chronic venous insufficiency.
The Cochrane database of systematic reviews (2012) · Meta analysis
Significantly reduced leg pain, edema, and itching vs placebo
Horse-chestnut seed extract for chronic venous insufficiency. A criteria-based systematic review.
Archives of dermatology (1998) · Systematic review
Most RCTs favored HCSE over placebo
Aescin: microcirculatory activity. Effects of accessory components on clinical and microcirculatory efficacy.
Panminerva medica (2011) · Open label
Improved microcirculatory parameters
Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II). A randomized, double-blind, placebo-controlled trial.
Arzneimittelforschung (2000) · Rct · n=260
Randomised, double-blind, placebo-controlled multicentre trial in 260 outpatients with stage I to incipient stage II chronic venous insufficiency, not using compression stockings: placebo, 360 mg or 720 mg once daily for 12 weeks
Efficacy and tolerability of a red-vine-leaf extract in patients suffering from chronic venous insufficiency--results of a double-blind placebo-controlled study.
Eur J Vasc Endovasc Surg (2011) · Rct · n=248
Registered (NCT00855179) randomised, double-blind, placebo-controlled multicentre trial of 720 mg/day for 12 weeks in people with CEAP C3 to C4a chronic venous insufficiency and moderate to severe symptoms. The full-analysis set was 248 (122 placebo, 126 extract)
Improvement of cutaneous microcirculation and oxygen supply in patients with chronic venous insufficiency by orally administered extract of red vine leaves AS 195: a randomised, double-blind, placebo-controlled, crossover study.
Drugs R D (2004) · Crossover · n=71
Randomised, double-blind, placebo-controlled crossover trial in 71 people with stage I or II chronic venous insufficiency: 360 mg once daily or placebo for 6 weeks, a 4-week washout, then the other treatment
Horse Chestnut has a higher evidence score (7/10 vs 5.4/10) and wins in 2 of 3 categories.
For leg circulation & vein health, Horse Chestnut has a higher relevance score (58 vs 40).
No known interactions between Horse Chestnut and Red Vine Leaf Extract have been documented in our database. However, always consult a healthcare provider before combining supplements.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.