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Head-to-head evidence comparison — which supplement is right for you?
Inositol wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Probably helps
14 of 21 studies with measurable effects showed benefit.
Top outcomes
Verdict
Mixed evidence
4 of 9 studies with measurable effects showed benefit.
Top outcomes
2-4g for general anxiety; 12-18g for OCD/panic
Divided into 2-3 doses, With or without food
Myo-inositol powder (most economical for higher doses)
300mg 3x daily (900mg total)
With meals, Divided into 2-3 doses
Standardized extract (0.3% hypericin)
4-6 weeks
6-12 weeks
3-6 months
First 1-2 weeks
4-6 weeks
4-8 weeks
During use
First 1-2 weeks
Antenatal dietary supplementation with myo-inositol for preventing gestational diabetes
The Cochrane database of systematic reviews (2023) · Meta analysis · n=1319
For the primary neonatal outcomes, only one study measured the risk of a large-for-gestational-age infant and found myo-inositol was associated with both appreciable benefit and harm (RR 1.40, 95% CI 0.65 to 3.02; 1 study, 234 infants; low-certainty evidence).
Inositol Nutritional Supplementation for the Prevention of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Nutrients (2022) · Meta analysis · n=1321
Pooled results were expressed as relative risk (RR) or mean difference (MD) with a 95% confidence interval (95% CI).
Antioxidants for female subfertility
The Cochrane database of systematic reviews (2020) · Meta analysis · n=7760
Due to the very low-quality of the evidence we are uncertain whether antioxidants improve live birth rate compared with placebo or no treatment/standard treatment (odds ratio (OR) 1.81, 95% confidence interval (CI) 1.36 to 2.43; P < 0.001, I2 = 29%; 13 RCTs, 1227 women).
St John's wort for major depression
Cochrane Database of Systematic Reviews (2008) · Meta analysis · n=5489
As effective as standard antidepressants for mild-moderate depression
Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis
Neuropsychopharmacology reports (2025) · Meta analysis · n=1049
A meta-analysis found no significant difference in response rates between the two treatments (risk ratio [RR] = 0.96, 95% CI: 0.78-1.18) or dropout rates (RR = 1.08, 95% CI: 0.62-1.88).
Systematic Review and Network Meta-Analysis of the Effects of Plant Extracts on Cognitive Function and Quality of Life in Stroke Patients
Phytotherapy research : PTR (2025) · Meta analysis
John's Wort extract (SUCRA 71.2%) was the most effective in reducing NIHSS scores, Berberine (SUCRA 84.1%) was most effective in reducing mRS scores, and St.
Based on multiple meta-analyses showing inositol benefits for PCOS including improved menstrual regularity, hormonal parameters, and metabolic markers. Evidence quality varies across studies with some limitations noted in systematic reviews.
Based on multiple meta-analyses (n>5000) showing efficacy comparable to SSRIs for mild-moderate depression. Effect plateau around 900-1200mg. Not effective for severe depression. Requires standardized extract (0.3% hypericin).
AI-estimated from published studies. Interpret as directional guidance.
Inositol has a higher evidence score (7/10 vs 7.8/10) and wins in 2 of 3 categories.
For support mood, St. John's Wort has a higher relevance score (92 vs 75).
No known interactions between Inositol and St. John's Wort have been documented in our database. However, always consult a healthcare provider before combining supplements.