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Head-to-head evidence comparison — which supplement is right for you?
Olive Leaf Extract wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mixed evidence
4 of 12 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
9 of 11 studies with measurable effects showed benefit.
Top outcomes
150-300mcg for maintenance; higher only if deficient under supervision
Any time with food
Potassium iodide (most common and studied)
500-1000mg (standardized to 15-20% oleuropein)
With meals
Standardized extract (15-20% oleuropein)
4-12 weeks
4-8 weeks
2-4 weeks
8 weeks
Maternal Iodine Status and Birth Outcomes: A Systematic Literature Review and Meta-Analysis
Nutrients (2023) · Meta analysis · n=42269
Birth weight was similar between UIC ≥ 150 μg/L and <150 μg/L (difference = 30 g, 95% CI −22 to 83, p = 0.3, n = 13, I2 = 89%) with no evidence of linear trend (4 g per 50 μg/L, −3 to 10, p = 0.2, n = 12, I2 = 80%).
Iodine fortification of foods and condiments, other than salt, for preventing iodine deficiency disorders
The Cochrane database of systematic reviews (2019) · Meta analysis · n=4317
This is equivalent to an increase of 38.32 µg/L (95% CI 24.03 to 52.61 µg/L).
Systematic review and meta-analysis of iodine nutrition in modern vegan and vegetarian diets
The British journal of nutrition (2023) · Meta analysis · n=4421
Vegan diets had the poorest iodine intake (17·3 µg/d) and were strongly associated with lower iodine intake (P = < 0·001) compared with omnivorous diets.
The impact of oleuropein, hydroxytyrosol, and tyrosol on cardiometabolic risk factors: a meta-analysis of randomized controlled trials
Critical reviews in food science and nutrition (2025) · Meta analysis · n=594
Fourteen human intervention studies with 594 participants were included.
Exploring the Benefits of Extra Virgin Olive Oil on Cardiovascular Health Enhancement and Disease Prevention: A Systematic Review
Nutrients (2025) · Systematic review
The beneficial effect was attributed to the polyphenols contained in EVOO.
Olive leaf extract effect on cardiometabolic risk factors: a systematic review and meta-analysis of randomized clinical trials
Nutrition reviews (2024) · Meta analysis · n=703
In the meta-analysis, fasting glycemia, as evaluated in studies using a low dose of OLE, showed a significant result favoring the control group.
Based on meta-analyses showing urinary iodine concentration increases with supplementation. Effects only meaningful in iodine-deficient populations. Excessive intake (>300mcg) may increase thyroid cancer risk. Most studies used potassium iodide; kelp-derived forms have variable bioavailability.
Based on RCT showing 6.4 mmHg SBP reduction, but one crossover trial showed no effect. Mixed results suggest conservative effectiveness estimates. Primarily studied in hypertensive populations.
AI-estimated from published studies. Interpret as directional guidance.
Olive Leaf Extract has a higher evidence score (7/10 vs 8.5/10) and wins in 2 of 3 categories.
No known interactions between Iodine and Olive Leaf Extract have been documented in our database. However, always consult a healthcare provider before combining supplements.