Head-to-head evidence comparison — which supplement is right for you?
Vitamin B6 wins 1 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
100-400mg daily
With meals, Can divide into 2-3 doses
Luteolin extract or Luteolin-quercetin complex
25-100mg daily
Morning with food, Can take with other B vitamins
P-5-P (Pyridoxal-5-Phosphate)
2-4 weeks
2-4 weeks
4-8 weeks
2-4 weeks
1-2 cycles
Months of high doses
Hepatoprotective activity of medicinal plants, their phytochemistry, and safety concerns: a systematic review
Zeitschrift fur Naturforschung. C, Journal of biosciences (2025) · Systematic review
The application of natural products derived from medicinal plants in treating liver injuries is rooted in their efficacy, cost-effectiveness, and safety profile, contributing to their popularity.
Intervention modalities for brain fog caused by long-COVID: systematic review of the literature
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2024) · Systematic review · n=17
Noninvasive brain stimulation and hyperbaric oxygen therapy showed promising results in the treatment of brain fog symptoms caused by long-COVID, with improved perfusion and cortical excitability.
Exploring the efficacy and molecular mechanism of Danhong injection comprehensively in the treatment of idiopathic pulmonary fibrosis by combining meta-analysis, network pharmacology, and molecular docking methods
Medicine (2024) · Meta analysis · n=896
These results provided scientific basis for the clinical use of Danhong injection for the treatment of IPF, and provided a new direction to explore the potential mechanism of action of Danhong injection.
Dosage exploration of combined B-vitamin supplementation in stroke prevention: a meta-analysis and systematic review
The American journal of clinical nutrition (2024) · Meta analysis · n=76664
In areas without and with partial folic acid fortification, combined B-vitamin supplementation significantly reduced the risk of stroke by 34% [RR: 0.66; 95% confidence interval (CI): 0.50, 0.86] and 11% (RR: 0.89; 95% CI: 0.79, 1.00), respectively.
Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression
Nutrients (2021) · Meta analysis · n=6276
Further, meta-regression showed no significant associations of treatment effects with any of the potential predictors.
Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life
The Cochrane database of systematic reviews (2018) · Meta analysis · n=83000
We found that giving B vitamin supplements to cognitively healthy adults, mainly in their 60s and 70s, probably has little or no effect on global cognitive function at any time point up to 5 years (SMD values from -0.03 to 0.06) and may also have no effect at 5-10 years (SMD -0.01).
Vitamin B6 has a higher evidence score (9/10 vs 8.5/10) and wins in 1 of 3 categories.
For support immune system, Vitamin B6 has a higher relevance score (65 vs 60).
No known interactions between Luteolin and Vitamin B6 have been documented in our database. However, always consult a healthcare provider before combining supplements.