Head-to-head evidence comparison — which supplement is right for you?
Vitamin D3 wins 1 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
100-400mg daily
With meals, Can divide into 2-3 doses
Luteolin extract or Luteolin-quercetin complex
2000-4000 IU daily
Morning with breakfast
D3 (cholecalciferol) softgel or liquid
2-4 weeks
2-4 weeks
4-8 weeks
4-8 weeks
4-8 weeks
2-4 weeks
4-8 weeks
Hepatoprotective activity of medicinal plants, their phytochemistry, and safety concerns: a systematic review
Zeitschrift fur Naturforschung. C, Journal of biosciences (2025) · Systematic review
The application of natural products derived from medicinal plants in treating liver injuries is rooted in their efficacy, cost-effectiveness, and safety profile, contributing to their popularity.
Intervention modalities for brain fog caused by long-COVID: systematic review of the literature
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2024) · Systematic review · n=17
Noninvasive brain stimulation and hyperbaric oxygen therapy showed promising results in the treatment of brain fog symptoms caused by long-COVID, with improved perfusion and cortical excitability.
Exploring the efficacy and molecular mechanism of Danhong injection comprehensively in the treatment of idiopathic pulmonary fibrosis by combining meta-analysis, network pharmacology, and molecular docking methods
Medicine (2024) · Meta analysis · n=896
These results provided scientific basis for the clinical use of Danhong injection for the treatment of IPF, and provided a new direction to explore the potential mechanism of action of Danhong injection.
Vitamin D supplementation vs. placebo and incident type 2 diabetes in an ancillary study of the randomized Vitamin D and Omega-3 Trial
Nature communications (2025) · Meta analysis · n=5205
Mean body mass index (BMI) was 27.5 kg/m2 (SD = 5.3), with 51% female and 17% Black race/ethnicity.
Vitamin D Supplementation for Patients with Dysmenorrhoea: A Meta-Analysis with Trial Sequential Analysis of Randomised Controlled Trials
Nutrients (2024) · Meta analysis · n=687
TSA revealed that the current RCTs provide sufficient information.
Effect of Vitamin D Supplementation in Early Life on Children's Growth and Body Composition: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Nutrients (2021) · Meta analysis · n=3960
Vitamin D supplementation during pregnancy was associated with higher triceps skinfold thickness (mm) (MD 0.33, 95% CI, 0.12, 0.54; I2 = 34%) in neonates.
Vitamin D3 has a higher evidence score (9/10 vs 8.5/10) and wins in 1 of 3 categories.
For support immune system, Vitamin D3 has a higher relevance score (92 vs 60).
No known interactions between Luteolin and Vitamin D3 have been documented in our database. However, always consult a healthcare provider before combining supplements.