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Head-to-head evidence comparison — which supplement is right for you?
Magnesium wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Probably helps
9 of 13 studies with measurable effects showed benefit.
Top outcomes
Verdict
Mostly mechanism / observational
Top outcomes
200-350mg elemental magnesium daily
Evening for sleep/relaxation (glycinate), Morning for energy (malate), Anytime (citrate)
Depends on goal - see notes
100-200mg daily
Morning or early afternoon, 30-60 minutes before focus work, Pre-workout
TeaCrine (branded theacrine)
1-2 weeks
1-2 weeks
1 week
Immediate
30-60 minutes, lasts 4-6 hours
30-60 minutes
30-60 minutes
30-60 minutes
Magnesium supplementation in pregnancy
The Cochrane database of systematic reviews (2014) · Meta analysis · n=9090
Women receiving magnesium were significantly less likely to require hospitalisation during pregnancy (RR 0.65, 95% CI 0.48 to 0.86; three trials, 1158 women).Of the 10 trials included in the review, only two were judged to be of high quality overall.
Magnesium Supplementation and Blood Pressure: A Systematic Review and Meta-Analysis
Nutrients (2024) · Meta analysis · n=2709
38 RCTs with 2709 participants analyzed
Magnesium and Potassium Supplementation for Systolic Blood Pressure Reduction in the General Normotensive Population: A Systematic Review and Subgroup Meta-Analysis for Optimal Dosage and Treatment Length
Nutrients (2024) · Meta analysis
Both supplements demonstrated greater reductions in SBP for the general population at lower dosages and longer treatment durations.
A caffeine and theacrine combination improves cognitive performance in tactical personnel under physically fatiguing conditions
Journal of the International Society of Sports Nutrition (2025) · Rct · n=20
In the Object Hit & Avoid task, CAF and CTC significantly improved task accuracy (p < 0.01) while reducing omission (p < 0.01) and commission errors (p < 0.01) compared to PLA.
Theacrine as a novel ergogenic aid: impact on canoe sprint performance
Journal of the International Society of Sports Nutrition (2025) · Rct · n=20
Caffeine significantly improved the 500-meter time trial (-1.872 s vs.
Uncovering the effects and mechanisms of tea and its components on depression, anxiety, and sleep disorders: A comprehensive review
Food research international (Ottawa, Ont.) (2024) · Systematic review
The underlying molecular mechanisms involve the regulation of neurotransmitters, including monoamines, GABA, and brain-derived neurotrophic factor (BDNF), as well as the suppression of oxidative stress and inflammation.
Based on meta-analysis of 38 RCTs with 2709 participants showing -7.68 mmHg reduction in hypertensive individuals. Effects are greatest in those with hypomagnesemia. Limited evidence in normotensive populations.
Effects are modest and inconsistent across studies. Several RCTs showed no significant cognitive improvements. Benefits appear primarily in subjective energy/focus rather than objective cognitive tasks. Studies show mixed results with some finding no statistical significance.
AI-estimated from published studies. Interpret as directional guidance.
Magnesium has a higher evidence score (8.5/10 vs 7.5/10) and wins in 2 of 3 categories.
For sharpen focus, Theacrine has a higher relevance score (75 vs 70).
No known interactions between Magnesium and Theacrine have been documented in our database. However, always consult a healthcare provider before combining supplements.