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Head-to-head evidence comparison — which supplement is right for you?
Phosphatidylserine wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
1 of 1 studies with measurable effects showed benefit.
Top outcomes
Verdict
Mostly mechanism / observational
Top outcomes
Shared outcomes (1)
Outcomes where both Phosphatidylserine and Theacrine have evidence — compare verdict strength side-by-side.
100-300mg daily
With meals, Evening or post-workout for cortisol
Soy or sunflower-derived phosphatidylserine
100-200mg daily
Morning or early afternoon, 30-60 minutes before focus work, Pre-workout
TeaCrine (branded theacrine)
4-12 weeks
2 weeks
4-8 weeks
30-60 minutes, lasts 4-6 hours
30-60 minutes
30-60 minutes
30-60 minutes
Effects of a food supplement containing phosphatidylserine on cognitive function in Chinese older adults with mild cognitive impairment: A randomized double-blind, placebo-controlled trial
Journal of affective disorders (2025) · Rct · n=190
A total of 190 participants (mean [SD] age, 67.95 [5.62] years; 70 (36.8 %) male and 120 (63.2 %) female) were randomized to the placebo group (n = 95) and intervention group (n = 95).
Dynamic release of extracellular particles after opening of the blood-brain barrier predicts glioblastoma susceptibility to paclitaxel
Nature communications (2025) · Rct
Thus, our study introduces an efficient microfluidic platform for the capture of circulating GBM EVPs and demonstrates that release upon BBB opening is predictive of outcomes following paclitaxel treatment.
Prognostic potential of lipid profiling in cancer patients: a systematic review of mass spectrometry-based studies
Lipids in health and disease (2024) · Systematic review · n=38
In conclusion, the potential for developing lipidomics in cancer prognostic prediction was demonstrated.
A caffeine and theacrine combination improves cognitive performance in tactical personnel under physically fatiguing conditions
Journal of the International Society of Sports Nutrition (2025) · Rct · n=20
In the Object Hit & Avoid task, CAF and CTC significantly improved task accuracy (p < 0.01) while reducing omission (p < 0.01) and commission errors (p < 0.01) compared to PLA.
Theacrine as a novel ergogenic aid: impact on canoe sprint performance
Journal of the International Society of Sports Nutrition (2025) · Rct · n=20
Caffeine significantly improved the 500-meter time trial (-1.872 s vs.
Uncovering the effects and mechanisms of tea and its components on depression, anxiety, and sleep disorders: A comprehensive review
Food research international (Ottawa, Ont.) (2024) · Systematic review
The underlying molecular mechanisms involve the regulation of neurotransmitters, including monoamines, GABA, and brain-derived neurotrophic factor (BDNF), as well as the suppression of oxidative stress and inflammation.
Based on RCT in 190 Chinese older adults with mild cognitive impairment and systematic review of neuronutrients. Limited by small number of direct studies and population-specific findings.
Effects are modest and inconsistent across studies. Several RCTs showed no significant cognitive improvements. Benefits appear primarily in subjective energy/focus rather than objective cognitive tasks. Studies show mixed results with some finding no statistical significance.
AI-estimated from published studies. Interpret as directional guidance.
Phosphatidylserine has a higher evidence score (8.5/10 vs 7.5/10) and wins in 2 of 3 categories.
For sharpen focus, Theacrine has a higher relevance score (75 vs 60).
No known interactions between Phosphatidylserine and Theacrine have been documented in our database. However, always consult a healthcare provider before combining supplements.