Head-to-head evidence comparison — which supplement is right for you?
Vitamin B12 wins 1 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
2-4g daily for PCOS; up to 12-18g for anxiety
Divided doses with meals, Morning and evening
Myo-inositol powder
500-1000mcg daily for maintenance; higher for deficiency
Morning (may be energizing), With or without food
Methylcobalamin (sublingual)
3-6 months
4-6 weeks
2-3 months
Initial use or high doses
2-4 weeks
4-8 weeks
Weeks to months
Antenatal dietary supplementation with myo-inositol for preventing gestational diabetes
The Cochrane database of systematic reviews (2023) · Meta analysis · n=1319
For the primary neonatal outcomes, only one study measured the risk of a large-for-gestational-age infant and found myo-inositol was associated with both appreciable benefit and harm (RR 1.40, 95% CI 0.65 to 3.02; 1 study, 234 infants; low-certainty evidence).
Inositol Nutritional Supplementation for the Prevention of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Nutrients (2022) · Meta analysis · n=1321
Pooled results were expressed as relative risk (RR) or mean difference (MD) with a 95% confidence interval (95% CI).
Short period-administration of myo-inositol and metformin on hormonal and glycolipid profiles in patients with polycystic ovary syndrome: a systematic review and updated meta-analysis of randomized controlled trials
European review for medical and pharmacological sciences (2022) · Meta analysis · n=612
Compared with metformin, the suitable supplemental dosage of myo-ins may be helpful in lowering levels of TG and avoiding adverse events (AEs).
Efficacy of different routes of vitamin B12 supplementation for the treatment of patients with vitamin B12 deficiency: A systematic review and network meta-analysis
Irish journal of medical science (2024) · Meta analysis · n=4275
Regarding the hemoglobin level, the pooled effect sizes showed no difference between all routes of administration that could reach statistical significance.
Dosage exploration of combined B-vitamin supplementation in stroke prevention: a meta-analysis and systematic review
The American journal of clinical nutrition (2024) · Meta analysis · n=76664
In areas without and with partial folic acid fortification, combined B-vitamin supplementation significantly reduced the risk of stroke by 34% [RR: 0.66; 95% confidence interval (CI): 0.50, 0.86] and 11% (RR: 0.89; 95% CI: 0.79, 1.00), respectively.
Vitamin Status in Patients with Phenylketonuria: A Systematic Review and Meta-Analysis
International journal of molecular sciences (2024) · Meta analysis · n=770
The effect sizes were expressed as standardised mean differences.
Vitamin B12 has a higher evidence score (9/10 vs 9/10) and wins in 1 of 3 categories.
For fertility support, Myo-Inositol has a higher relevance score (92 vs 70).
No known interactions between Myo-Inositol and Vitamin B12 have been documented in our database. However, always consult a healthcare provider before combining supplements.