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Head-to-head evidence comparison — which supplement is right for you?
NAC vs Sulforaphane: NAC has the stronger overall evidence (6 vs 5.5/10); they're alternatives for liver & detox support — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
NAC wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
7 of 8 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
5 of 6 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (2)
Outcomes where both NAC and Sulforaphane have evidence — compare verdict strength side-by-side.
600-1800mg daily
Away from food, Split into 2-3 doses
NAC capsules or powder
10-50mg sulforaphane (or equivalent from broccoli sprout extract)
With meals, Morning preferred
Stabilized sulforaphane (Prostaphane, Avmacol) or broccoli sprout extract with myrosinase
4-8 weeks
2-4 weeks
1-2 weeks
Immediate
2-4 weeks
2-4 weeks
1-2 weeks
Efficacy of N-Acetylcysteine in Polycystic Ovary Syndrome: Systematic Review and Meta-Analysis
Nutrients (2025) · Meta analysis · n=2515
NAC was associated with a statistically significant increase in progesterone (SMD 0.95, 95% CI: 0.13-1.77, p = 0.02) and endometrial thickness (SMD 0.58, 95% CI: 0.10-1.06, p = 0.02) compared to the placebo and other drugs (SMD 0.71, 95% CI: 0.48-0.94, p < 0.0001).
Efficacy of N-acetylcysteine for patients with depression: An updated systematic review and meta-analysis
General hospital psychiatry (2024) · Meta analysis · n=904
Our findings indicate that adjunctive NAC can ameliorate depressive symptoms in patients with psychiatric problems, particularly bipolar disorder.
N-acetylcysteine as a treatment for substance use cravings: A meta-analysis
Addiction biology (2024) · Meta analysis · n=623
The most targeted substance in the clinical trials was alcohol (3/9; 33.3%), followed by tobacco (2/9; 22.2%) and multiple substances (2/9; 22.2%).
Broccoli Consumption and Risk of Cancer: An Updated Systematic Review and Meta-Analysis of Observational Studies
Nutrients (2024) · Meta analysis · n=31292
In summary, the findings indicate that individuals suffering from some type of cancer consumed less broccoli, suggesting a protective biological effect of broccoli on cancer.
Do Brassica Vegetables Affect Thyroid Function?-A Comprehensive Systematic Review
International journal of molecular sciences (2024) · Systematic review
We analyzed the results of 123 articles of in vitro, animal, and human studies, describing the impact of brassica plants and extracts on thyroid mass and histology, blood levels of TSH, T3, T4, iodine uptake, and the effect on thyroid cancer cells.
Potential Effects of Bioactive Compounds of Plant-Based Foods and Medicinal Plants in Chronic Kidney Disease and Dialysis: A Systematic Review
Nutrients (2024) · Systematic review
Systematic review examining Sulforaphane efficacy
Meta-analysis showed efficacy particularly in bipolar disorder patients. Effect appears as adjunctive treatment. Individual response varies significantly.
Based on meta-analyses showing significant improvements in Social Responsiveness Scale and irritability/hyperactivity scores. Effects were modest and required 4-10 weeks of supplementation. Limited to autism populations only.
AI-estimated from published studies. Interpret as directional guidance.
NAC has a higher evidence score (6/10 vs 5.5/10) and wins in 2 of 3 categories.
For liver & detox support, NAC has a higher relevance score (90 vs 85).
No known interactions between NAC and Sulforaphane have been documented in our database. However, always consult a healthcare provider before combining supplements.
Weight loss is the real treatment; vitamin E/omega-3 have some evidence, milk thistle modest, TUDCA thin.
Folate is essential; inositol + CoQ10 are the best bets — but conception evidence is limited.
Inositol (40:1), and the supporting cast for insulin resistance, cycles & fertility.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.