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Head-to-head evidence comparison — which supplement is right for you?
Nicotinamide Riboside vs Sage: Nicotinamide Riboside has the stronger overall evidence (5.5 vs 6/10); they're alternatives for improve memory & learning — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Nicotinamide Riboside wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Too few graded studies
Top outcomes
Verdict
Too few graded studies
1 of 1 studies with measurable effects showed benefit.
Top outcomes
1000 mg daily (the dose used in most outcome trials; lower doses raise blood NAD+ but have not been tested for clinical effects)
Morning with breakfast, Split dosing (morning and midday) for doses above 500 mg
Nicotinamide Riboside Chloride capsules or powder
300–600 mg standardized extract daily
With breakfast, With dinner (split dosing)
Standardized extract (300–600 mg, 2.5% rosmarinic acid)
and 1 more not shown
and 4 more not shown
1–2 weeks
4–8 weeks
8–16 weeks
4–8 weeks
4–8 weeks
4–8 weeks
4–8 weeks
8–12 weeks
NAD⁺ supplementation for anti-aging and wellness: A PRISMA-guided systematic review of preclinical and clinical evidence.
Ageing Research Reviews (2026) · Systematic review
Reviewed 113 intervention studies published from 2010 to October 2025: 33 in humans (28 of them randomised) and 80 in rodents, covering NR, NMN and injected NAD+.
The Effect of Nicotinamide Mononucleotide and Riboside on Skeletal Muscle Mass and Function: A Systematic Review and Meta-Analysis.
Journal of Cachexia, Sarcopenia and Muscle (2025) · Meta analysis
Systematic review and meta-analysis of placebo-controlled RCTs of NMN or NR in adults with a mean age of 60.9 to 83 years, looking at muscle mass, grip strength, gait speed and other physical performance tests.
Effects of NAD+ precursor supplementation on glucose and lipid metabolism in humans: a meta-analysis.
Nutrition & Metabolism (2022) · Meta analysis · n=14750
Meta-analysis of 40 clinical studies (14,750 participants) of four NAD+ precursors: nicotinamide riboside, nicotinamide mononucleotide, nicotinic acid (niacin) and nicotinamide.
Systematic review of clinical trials assessing pharmacological properties of Salvia species on memory, cognitive impairment and Alzheimer's disease.
CNS Neuroscience & Therapeutics (2014) · Systematic review
Eight clinical studies were included: six on cognitive performance in healthy subjects and two on Alzheimer's disease.
Exploring the therapeutic impact of Salvia officinalis on lipid and oxidative stress markers in patients with polycystic ovary syndrome - a randomized placebo-controlled clinical trial.
BMC Complementary Medicine and Therapies (2025) · Rct · n=70
70 women with newly diagnosed PCOS were randomized to receive either 330 mg of S. officinalis extract or placebo daily for eight weeks.
Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease
J Clin Pharm Ther (2003) · Rct · n=42
42 patients aged 65-80 with mild to moderate Alzheimer's disease were randomized to a fixed dose of S. officinalis extract (60 drops/day) or placebo for 4 months.
The points come from one 8-week RCT in overweight adults, where 100, 300 and 1,000 mg a day raised whole-blood NAD+ by 22%, 51% and 142%, with no difference in adverse events versus placebo or between doses (PMID 31278280). Other trials at 1 g a day found similar rises, 2.6-fold in older adults with mild cognitive impairment (PMID 37994989). No trial compared doses above 1,000 mg, so no optimal dose is plotted. The ceiling is the 2,000 mg a day that a 12-week RCT in obese men found safe (PMID 29992272). The NR-SAFE trial also found 3,000 mg a day well tolerated over 4 weeks in 10 people with Parkinson's disease (PMID 38016950).
Based on multiple RCTs showing improvements in word recall, working memory, and attention. Effects varied by specific cognitive domain and population. Most studies used standardized extracts.
AI-estimated from published studies. Interpret as directional guidance.
Nicotinamide Riboside has a higher evidence score (5.5/10 vs 6/10) and wins in 2 of 3 categories.
For improve memory & learning, Sage has a higher relevance score (78 vs 15).
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
NAD+ boosters raise a biomarker — but the anti-aging benefits aren’t proven in humans. The honest read.
Hot flashes, bone, sleep, muscle — the basics that hold up vs the phytoestrogen hype.
What’s safe while nursing, the truth about milk-supply herbs, and what to avoid (it passes into milk).
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.