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Head-to-head evidence comparison — which supplement is right for you?
Omega-3 wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Probably helps
18 of 27 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
12 of 13 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Omega-3 and Vitex have evidence — compare verdict strength side-by-side.
2-3g combined EPA+DHA daily
With meals containing fat
Triglyceride form fish oil
20-40mg extract (standardized to 0.5% agnuside)
Morning, Consistently at same time daily
Standardized extract (0.5% agnuside or 0.6% aucubin)
4-8 weeks
2-4 weeks
Immediate
4-12 weeks
1-3 cycles
2-3 cycles
1-2 cycles
Marine n-3 Fatty Acids and Prevention of Cardiovascular Disease and Cancer
The New England journal of medicine (2019) · Rct · n=25871
During a median follow-up of 5.3 years, a major cardiovascular event occurred in 386 participants in the n-3 group and in 419 in the placebo group (hazard ratio, 0.92; 95% confidence interval [CI], 0.80 to 1.06; P=0.24).
Omega-3 fatty acids for intermittent claudication
The Cochrane database of systematic reviews (2024) · Meta analysis · n=1830
Omega-3 compared with a control may have little to no effect on ankle-brachial index (MD -0.02, 95% CI -0.08 to 0.04; 3 studies, 168 participants; very low-certainty evidence).
A systematic review and meta-analysis of the omega-3 fatty acids effects on brain-derived neurotrophic factor (BDNF)
Nutritional neuroscience (2024) · Meta analysis · n=587
The present systematic review and meta-analysis indicate the efficacy of omega-3 FAs in increasing the serum concentration of BDNF.
Vitex agnus-castus in premenstrual syndrome: A meta-analysis of double-blind randomised controlled trials
Complementary Therapies in Medicine (2019) · Meta analysis · n=1878
Vitex significantly reduced overall PMS symptom scores vs placebo
Herbal medicine for depression and anxiety: A systematic review with assessment of potential psycho-oncologic relevance
Phytotherapy research : PTR (2018) · Systematic review
Overall, 45% of studies reported positive findings with fewer adverse effects compared with conventional medications.
A Critical Approach to Evaluating Clinical Efficacy, Adverse Events and Drug Interactions of Herbal Remedies
Phytotherapy research : PTR (2016) · Review
A critical evaluation of the clinical data regarding the adverse effects has shown that herbal remedies are generally better tolerated than synthetic medications.
Based on multiple meta-analyses showing EPA-dominant formulas >1g/day most effective. Effects plateau around 2-2.5g. Adjunctive use with antidepressants shows better outcomes than monotherapy.
Based on meta-analysis of RCTs showing large effect size. Most effective for irritability, mood swings, and breast tenderness. Standardized extracts (Ze 440, BNO 1095) had strongest evidence. High heterogeneity noted between studies.
AI-estimated from published studies. Interpret as directional guidance.
Omega-3 has a higher evidence score (9/10 vs 7/10) and wins in 2 of 3 categories.
For support mood, Vitex has a higher relevance score (90 vs 88).
No known interactions between Omega-3 and Vitex have been documented in our database. However, always consult a healthcare provider before combining supplements.