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Head-to-head evidence comparison — which supplement is right for you?
Probiotics vs Vitex: Probiotics has the stronger overall evidence (9 vs 7/10); they're alternatives for support mood — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Probiotics wins 3 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
12 of 13 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
3 of 4 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (2)
Outcomes where both Probiotics and Vitex have evidence — compare verdict strength side-by-side.
10-20 billion CFU (no cited trial states the dose it used)
With or without food (strain-dependent), Same time daily for consistency
Capsules with multiple strains
20-40mg extract (standardized to 0.5% agnuside). The cited trials used 20 to 30 mg of extract a day.
Morning, Consistently at same time daily
Standardized extract (0.5% agnuside or 0.6% aucubin)
and 1 more not shown
2-4 weeks
4-8 weeks
4-8 weeks
First 1-2 weeks
1-3 cycles
2-3 cycles
1-2 cycles
Preventive Effect of Probiotics on Oral Mucositis Induced by Cancer Treatment: A Systematic Review and Meta-Analysis
International journal of molecular sciences (2022) · Meta analysis · n=708
Three trials using Lactobacilli-based probiotics reported that the incidence of oral mucositis in the probiotic group was significantly low (risk ratio [RR] = 0.84, 95% confidence interval [CI] = 0.77−0.93, p = 0.0004).
Probiotics for treating acute infectious diarrhoea
The Cochrane database of systematic reviews (2020) · Meta analysis · n=12127
Effect size was similar in the sensitivity analysis and marked heterogeneity persisted.
Probiotics for the prevention of Clostridioides difficile-associated diarrhea in adults and children.
The Cochrane database of systematic reviews (2025) · Meta analysis · n=9955
Probiotics may prevent CDAD: NNTB 65 (95% CI 48 to 97)
Vitex agnus-castus in premenstrual syndrome: A meta-analysis of double-blind randomised controlled trials
Complementary Therapies in Medicine (2019) · Meta analysis · n=520
Out of 21 clinical trials, three double-blind placebo-controlled studies (520 females) met the reporting criteria, testing the characterised extracts Ze 440 and BNO 1095.
Herbal medicine for depression and anxiety: A systematic review with assessment of potential psycho-oncologic relevance
Phytotherapy research : PTR (2018) · Systematic review
Overall, 45% of studies reported positive findings with fewer adverse effects compared with conventional medications.
A Critical Approach to Evaluating Clinical Efficacy, Adverse Events and Drug Interactions of Herbal Remedies
Phytotherapy research : PTR (2016) · Review
A critical narrative review of published systematic reviews and meta-analyses of herbal remedies. It pools no data of its own.
The points come from one dose-finding RCT of the Ze 440 extract in 162 women with PMS over three cycles, at 8, 20 or 30 mg a day (PMID 23022391). Total symptom scores improved more at 20 mg than with placebo or 8 mg, and 30 mg did not improve them further than 20 mg, so the curve is flat above 20 mg. All three doses were well tolerated, and no higher dose of this extract was tested. A meta-analysis of 3 trials of characterised extracts (Ze 440, BNO 1095; 520 women) found Vitex users 2.57 times more likely to remit (PMID 31780016). A broader pooled effect was large but rated explorative because of high risk of bias, heterogeneity (I² 91%) and publication bias (PMID 28237870).
AI-estimated from published studies. Interpret as directional guidance.
Probiotics has a higher evidence score (9/10 vs 7/10) and wins in 3 of 3 categories.
For support mood, Vitex has a higher relevance score (90 vs 60).
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
The honest tier list — proven staples vs situational vs mostly marketing. The hub the other guides feed into.
On Ozempic/Wegovy/Mounjaro? What actually helps — muscle preservation, GI relief, nutrient gaps (no upsell).
Saffron, EPA omega-3, SAMe have real adjunct evidence — but these aren’t a substitute for care, and some interact dangerously.
Probiotics vs prebiotics vs synbiotics, the CFU myth, and what actually helps bloating.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.