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Head-to-head evidence comparison — which supplement is right for you?
Probiotics wins 3 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
30 of 39 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
12 of 13 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Probiotics and Vitex have evidence — compare verdict strength side-by-side.
10-20 billion CFU
With or without food (strain-dependent), Same time daily for consistency
Capsules with multiple strains
20-40mg extract (standardized to 0.5% agnuside)
Morning, Consistently at same time daily
Standardized extract (0.5% agnuside or 0.6% aucubin)
2-4 weeks
4-8 weeks
4-8 weeks
First 1-2 weeks
1-3 cycles
2-3 cycles
1-2 cycles
Preventive Effect of Probiotics on Oral Mucositis Induced by Cancer Treatment: A Systematic Review and Meta-Analysis
International journal of molecular sciences (2022) · Meta analysis · n=708
Three trials using Lactobacilli-based probiotics reported that the incidence of oral mucositis in the probiotic group was significantly low (risk ratio [RR] = 0.84, 95% confidence interval [CI] = 0.77−0.93, p = 0.0004).
Probiotics for treating acute infectious diarrhoea
The Cochrane database of systematic reviews (2020) · Meta analysis · n=12127
Effect size was similar in the sensitivity analysis and marked heterogeneity persisted.
Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children
The Cochrane database of systematic reviews (2017) · Meta analysis · n=9955
A complete case analysis (i.e. participants who completed the study) among trials investigating CDAD (31 trials, 8672 participants) suggests that probiotics reduce the risk of CDAD by 60%.
Vitex agnus-castus in premenstrual syndrome: A meta-analysis of double-blind randomised controlled trials
Complementary Therapies in Medicine (2019) · Meta analysis · n=1878
Vitex significantly reduced overall PMS symptom scores vs placebo
Herbal medicine for depression and anxiety: A systematic review with assessment of potential psycho-oncologic relevance
Phytotherapy research : PTR (2018) · Systematic review
Overall, 45% of studies reported positive findings with fewer adverse effects compared with conventional medications.
A Critical Approach to Evaluating Clinical Efficacy, Adverse Events and Drug Interactions of Herbal Remedies
Phytotherapy research : PTR (2016) · Review
A critical evaluation of the clinical data regarding the adverse effects has shown that herbal remedies are generally better tolerated than synthetic medications.
Based on meta-analyses showing benefits for IBS and digestive symptoms. Effect sizes varied considerably between studies with low to very low certainty of evidence. Initial GI symptoms common when starting but typically resolve within 1-2 weeks.
Based on meta-analysis of RCTs showing large effect size. Most effective for irritability, mood swings, and breast tenderness. Standardized extracts (Ze 440, BNO 1095) had strongest evidence. High heterogeneity noted between studies.
AI-estimated from published studies. Interpret as directional guidance.
Probiotics has a higher evidence score (9/10 vs 7/10) and wins in 3 of 3 categories.
For support mood, Vitex has a higher relevance score (90 vs 60).
No known interactions between Probiotics and Vitex have been documented in our database. However, always consult a healthcare provider before combining supplements.