Loading…
We use essential cookies (authentication, your saved goals/stack) by default. With your permission we’ll also enable privacy-respecting analytics (Vercel Web Analytics, anonymous load-time metrics) and error-replay diagnostics (Sentry — DOM snapshots only when an error fires) so we can fix bugs faster. Learn more about cookies
Head-to-head evidence comparison — which supplement is right for you?
Probiotics vs Red Vine Leaf Extract: Probiotics has the stronger overall evidence (9 vs 5.4/10); the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Probiotics wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
13 of 14 studies with measurable effects showed benefit.
Top outcomes
Verdict
Too few graded studies
Top outcomes
10-20 billion CFU (no cited trial states the dose it used)
With or without food (strain-dependent), Same time daily for consistency
Capsules with multiple strains
360 mg standardised red vine leaf extract once daily, up to 720 mg once daily. These are the doses given in the placebo-controlled trials, for 6 to 12 weeks.
Any time of day
Standardised red vine leaf dry extract, 360 to 720 mg
2-4 weeks
4-8 weeks
4-8 weeks
First 1-2 weeks
6-12 weeks
6-12 weeks
Days
Preventive Effect of Probiotics on Oral Mucositis Induced by Cancer Treatment: A Systematic Review and Meta-Analysis
International journal of molecular sciences (2022) · Meta analysis · n=708
Three trials using Lactobacilli-based probiotics reported that the incidence of oral mucositis in the probiotic group was significantly low (risk ratio [RR] = 0.84, 95% confidence interval [CI] = 0.77−0.93, p = 0.0004).
Probiotics for treating acute infectious diarrhoea
The Cochrane database of systematic reviews (2020) · Meta analysis · n=12127
Effect size was similar in the sensitivity analysis and marked heterogeneity persisted.
Probiotics for the prevention of Clostridioides difficile-associated diarrhea in adults and children.
The Cochrane database of systematic reviews (2025) · Meta analysis · n=9955
Probiotics may prevent CDAD: NNTB 65 (95% CI 48 to 97)
Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II). A randomized, double-blind, placebo-controlled trial.
Arzneimittelforschung (2000) · Rct · n=260
Randomised, double-blind, placebo-controlled multicentre trial in 260 outpatients with stage I to incipient stage II chronic venous insufficiency, not using compression stockings: placebo, 360 mg or 720 mg once daily for 12 weeks
Efficacy and tolerability of a red-vine-leaf extract in patients suffering from chronic venous insufficiency--results of a double-blind placebo-controlled study.
Eur J Vasc Endovasc Surg (2011) · Rct · n=248
Registered (NCT00855179) randomised, double-blind, placebo-controlled multicentre trial of 720 mg/day for 12 weeks in people with CEAP C3 to C4a chronic venous insufficiency and moderate to severe symptoms. The full-analysis set was 248 (122 placebo, 126 extract)
Improvement of cutaneous microcirculation and oxygen supply in patients with chronic venous insufficiency by orally administered extract of red vine leaves AS 195: a randomised, double-blind, placebo-controlled, crossover study.
Drugs R D (2004) · Crossover · n=71
Randomised, double-blind, placebo-controlled crossover trial in 71 people with stage I or II chronic venous insufficiency: 360 mg once daily or placebo for 6 weeks, a 4-week washout, then the other treatment
Probiotics has a higher evidence score (9/10 vs 5.4/10) and wins in 2 of 3 categories.
No known interactions between Probiotics and Red Vine Leaf Extract have been documented in our database. However, always consult a healthcare provider before combining supplements.
The honest tier list — proven staples vs situational vs mostly marketing. The hub the other guides feed into.
On Ozempic/Wegovy/Mounjaro? What actually helps — muscle preservation, GI relief, nutrient gaps (no upsell).
Saffron, EPA omega-3, SAMe have real adjunct evidence — but these aren’t a substitute for care, and some interact dangerously.
Probiotics vs prebiotics vs synbiotics, the CFU myth, and what actually helps bloating.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.