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Head-to-head evidence comparison — which supplement is right for you?
Saccharomyces Boulardii wins 3 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
10 of 10 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
13 of 15 studies with measurable effects showed benefit.
Top outcomes
300-1000mg daily (standardized extract)
With food, Divided doses for higher amounts, Throat spray can be used as needed
Standardized extract (capsules or tincture)
250-500mg (5-10 billion CFU) daily
With or without food, At least 2 hours away from antifungals
Capsules (lyophilized)
1-2 weeks
2-4 weeks
1-2 weeks
Acute
During use
1-3 days
1-2 weeks
Dosage exploration of the effects of honey and its derivatives on cardiometabolic outcomes: an overview of systematic reviews and GRADE-assessed updated meta-analysis
Nutrition & diabetes (2025) · Meta analysis · n=3544
Propolis demonstrated reductions in anthropometric measures and improvements in lipid profile, glycemic control, liver enzymes, and inflammation and oxidative stress markers.
The impact of propolis supplementation on inflammatory biomarkers: A meta-analysis and systematic review of randomized controlled clinical trials
Prostaglandins & other lipid mediators (2024) · Meta analysis · n=1139
The propolis supplementation significantly reduced IL-6 (WMD = -2.48; 95 % CI: -4.62, -0.34; P = 0.023) and TNF-α (WMD = -0.86; 95 % CI: -1.45, -0.26; P = 0.005) compared with control groups.
Potential Effects of Bioactive Compounds of Plant-Based Foods and Medicinal Plants in Chronic Kidney Disease and Dialysis: A Systematic Review
Nutrients (2024) · Systematic review
Systematic review examining Propolis efficacy
Efficacy and safety of Saccharomyces boulardii as an adjuvant therapy for the eradication of Helicobacter pylori: a meta-analysis
Frontiers in cellular and infection microbiology (2025) · Meta analysis · n=5036
S. boulardii supplementation in traditional eradication therapy significantly improves the H. pylori eradication rate and reduces the total adverse effects and incidence of diarrhea, bloating, constipation, and nausea.
Probiotics for treating acute infectious diarrhoea
The Cochrane database of systematic reviews (2020) · Meta analysis · n=12127
Effect size was similar in the sensitivity analysis and marked heterogeneity persisted.
The use of probiotics and prebiotics in decolonizing pathogenic bacteria from the gut; a systematic review and meta-analysis of clinical outcomes
Gut microbes (2024) · Meta analysis · n=2871
This review aims to analyze available evidence from human-controlled trials to determine the effect size of probiotic interventions in decolonizing AMR pathogenic bacteria from the gut.
Based on meta-analyses showing significant reductions in IL-6, TNF-α, and CRP. Effect sizes were modest with WMD of -2.48 for IL-6 and -0.86 for TNF-α. Conservative effectiveness reflects variable study quality and heterogeneity between trials.
Based on multiple meta-analyses showing 1.1-1.6 day reduction in diarrhea duration. Effect size appears to plateau at standard therapeutic doses. Limited data on doses above 20 billion CFU.
AI-estimated from published studies. Interpret as directional guidance.
Saccharomyces Boulardii has a higher evidence score (8.5/10 vs 5.5/10) and wins in 3 of 3 categories.
For reduce inflammation, Saccharomyces Boulardii has a higher relevance score (90 vs 60).
No known interactions between Propolis and Saccharomyces Boulardii have been documented in our database. However, always consult a healthcare provider before combining supplements.