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Head-to-head evidence comparison — which supplement is right for you?
Pterostilbene vs Red Yeast Rice: Red Yeast Rice has the stronger overall evidence (7.8 vs 4/10); they're alternatives for support heart health — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Red Yeast Rice wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Likely helps
7 of 7 studies with measurable effects showed benefit.
Top outcomes
50-100mg daily
Morning with breakfast, Can be divided into two doses
Pterostilbene capsules
1200-2400mg providing 10mg monacolin K
Evening (cholesterol synthesis peaks at night)
Standardized extract with verified monacolin K content
and 4 more not shown
4-8 weeks
6-12 weeks
4-8 weeks
Weeks
8-12 weeks
8-12 weeks
Resveratrol and Its Analogues: Anti-ageing Effects and Underlying Mechanisms
Sub-cellular biochemistry (2024) · Review
The anti-ageing mechanisms of resveratrol and its analogues are complex and multifactorial, involving suppressing oxidative stress, ameliorating inflammation, activating SIRT1 pathway, reducing DNA damage, etc.
Antiobesity pathways of pterostilbene and resveratrol: a comprehensive insight
Critical reviews in food science and nutrition (2024) · Review
Stilbenes are products of the plant phenylpropanoid pathway.
Dietary Supplementation With NAD+-Boosting Compounds in Humans: Current Knowledge and Future Directions
The journals of gerontology. Series A, Biological sciences and medical sciences (2023) · Review
Review of chronic oral NAD+ precursor supplementation in humans. Nicotinamide riboside given with pterostilbene was one of the three most studied options.
Efficacy and Safety of Armolipid Plus(®): An Updated PRISMA Compliant Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials
Nutrients (2021) · Meta analysis · n=1050
Armolipid Plus® was well tolerated.
Safety and Efficacy of the Consumption of the Nutraceutical "Red Yeast Rice Extract" for the Reduction of Hypercholesterolemia in Humans: A Systematic Review and Meta-Analysis
Nutrients (2024) · Meta analysis
The consumption of RYR extract by people with hypercholesterolemia was associated with statistically significant reduction in total cholesterol and LDL-C, whereas it was not associated with an increase in life-threatening side effects.
Impact of Berberine or Berberine Combination Products on Lipoprotein, Triglyceride and Biological Safety Marker Concentrations in Patients with Hyperlipidemia: A Systematic Review and Meta-Analysis
Journal of dietary supplements (2024) · Meta analysis · n=4838
Meta-analysis of 41 randomized trials (4,838 patients) of berberine products, alone or combined with other nutraceuticals such as red yeast rice, for 8-18 weeks.
Both points come from one 8-week randomised trial in 105 people with mild high cholesterol (PMID 37375586): LDL fell by 16.77% on 3 mg of monacolin K and by 26.46% on 10 mg, on top of lifestyle change, and effectiveness is that percentage fall. The product also contained CoQ10, grape seed and olive leaf extracts, and no severe adverse events occurred. A separate 8-week trial of 200 mg red yeast rice with 2 mg monacolin K in 18 people lowered LDL more than diet alone (PMID 34587702). The 6 mg point was removed because no cited trial tested it, and no cited trial tested more than 10 mg.
AI-estimated from published studies. Interpret as directional guidance.
Red Yeast Rice has a higher evidence score (7.8/10 vs 4/10) and wins in 2 of 3 categories.
For support heart health, Red Yeast Rice has a higher relevance score (90 vs 52).
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.