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Head-to-head evidence comparison — which supplement is right for you?
SAMe wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
1 of 1 studies with measurable effects showed benefit.
Top outcomes
Verdict
Mostly mechanism / observational
0 of 2 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Pterostilbene and SAMe have evidence — compare verdict strength side-by-side.
50-100mg daily
Morning with breakfast, Can be divided into two doses
Pterostilbene capsules
400-1600mg for mood; 600-1200mg for joints
On empty stomach, Morning and/or midday
Enteric-coated tablets (SAMe tosylate or butanedisulfonate)
4-8 weeks
6-12 weeks
4-8 weeks
Weeks
2-6 weeks
4-8 weeks
4-8 weeks
Resveratrol and Its Analogues: Anti-ageing Effects and Underlying Mechanisms
Sub-cellular biochemistry (2024) · Systematic review
The anti-ageing mechanisms of resveratrol and its analogues are complex and multifactorial, involving suppressing oxidative stress, ameliorating inflammation, activating SIRT1 pathway, reducing DNA damage, etc.
Antiobesity pathways of pterostilbene and resveratrol: a comprehensive insight
Critical reviews in food science and nutrition (2024) · Systematic review
Stilbenes are products of the plant phenylpropanoid pathway.
Dietary Supplementation With NAD+-Boosting Compounds in Humans: Current Knowledge and Future Directions
The journals of gerontology. Series A, Biological sciences and medical sciences (2023) · Systematic review
Limitations are identified and future research directions are suggested to further our understanding of the potential efficacy of NAD+-boosting compounds for improving physiological function and extending human health span.© The Author(s) 2023.
S-Adenosylmethionine for osteoarthritis of the knee or hip
The Cochrane database of systematic reviews (2009) · Meta analysis · n=656
For pain, the analysis indicated a small SMD of -0.17 (95% CI -0.34 to 0.01), corresponding to a difference in pain scores between SAMe and placebo of 0.4 cm on a 10 cm VAS, with no between trial heterogeneity (I(2) = 0).
Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis
Neuropsychopharmacology reports (2025) · Meta analysis · n=1049
A meta-analysis found no significant difference in response rates between the two treatments (risk ratio [RR] = 0.96, 95% CI: 0.78-1.18) or dropout rates (RR = 1.08, 95% CI: 0.62-1.88).
S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review
Nutrients (2024) · Systematic review · n=15
The most common doses were SAMe 1000 mg or 1200 mg per day with or without another treatment or natural supplement.
Based on RCT with n=111 NAFLD patients showing reduced hepatic inflammation markers and ceramide 14:0 levels. Conservative estimate given single study and disease-specific population.
Meta-analysis of 656 patients showed small effect size (SMD -0.17) corresponding to only 0.4cm improvement on 10cm pain scale. Effect is modest and barely reaches statistical significance threshold.
AI-estimated from published studies. Interpret as directional guidance.
SAMe has a higher evidence score (9/10 vs 7/10) and wins in 2 of 3 categories.
For reduce inflammation, SAMe has a higher relevance score (80 vs 50).
No known interactions between Pterostilbene and SAMe have been documented in our database. However, always consult a healthcare provider before combining supplements.