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Head-to-head evidence comparison — which supplement is right for you?
Vitex wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mixed evidence
2 of 5 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
12 of 13 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Raspberry Leaf and Vitex have evidence — compare verdict strength side-by-side.
1-2g dried leaf as tea, 2-3 times daily
Between meals as tea, Divided throughout the day
Dried leaf tea
20-40mg extract (standardized to 0.5% agnuside)
Morning, Consistently at same time daily
Standardized extract (0.5% agnuside or 0.6% aucubin)
2-3 cycles
Last trimester
1-3 cycles
2-3 cycles
1-2 cycles
Raspberry Leaves and Extracts-Molecular Mechanism of Action and Its Effectiveness on Human Cervical Ripening and the Induction of Labor
Nutrients (2023) · Systematic review
The majority of women apply raspberry leaves during pregnancy to induce and ease labor.
A Review on Berry Seeds-A Special Emphasis on Their Chemical Content and Health-Promoting Properties
Nutrients (2023) · Systematic review
Last search was conducted on 16.01.2023.
Phenolic Composition, Mineral Content, and Beneficial Bioactivities of Leaf Extracts from Black Currant (Ribes nigrum L.), Raspberry (Rubus idaeus), and Aronia (Aronia melanocarpa)
Nutrients (2020) · Systematic review
This was reviewed and discussed in this article.
Vitex agnus-castus in premenstrual syndrome: A meta-analysis of double-blind randomised controlled trials
Complementary Therapies in Medicine (2019) · Meta analysis · n=1878
Vitex significantly reduced overall PMS symptom scores vs placebo
Herbal medicine for depression and anxiety: A systematic review with assessment of potential psycho-oncologic relevance
Phytotherapy research : PTR (2018) · Systematic review
Overall, 45% of studies reported positive findings with fewer adverse effects compared with conventional medications.
A Critical Approach to Evaluating Clinical Efficacy, Adverse Events and Drug Interactions of Herbal Remedies
Phytotherapy research : PTR (2016) · Review
A critical evaluation of the clinical data regarding the adverse effects has shown that herbal remedies are generally better tolerated than synthetic medications.
Based on single RCT (n=37) showing 25.6% glucose reduction when tea consumed with sucrose. Conservative estimate due to limited study population and single trial. Effect may be specific to tea preparation and timing with carbohydrate intake.
Based on meta-analysis of RCTs showing large effect size. Most effective for irritability, mood swings, and breast tenderness. Standardized extracts (Ze 440, BNO 1095) had strongest evidence. High heterogeneity noted between studies.
AI-estimated from published studies. Interpret as directional guidance.
Vitex has a higher evidence score (7/10 vs 4/10) and wins in 2 of 3 categories.
For testosterone & cortisol balance, Vitex has a higher relevance score (92 vs 48).
No known interactions between Raspberry Leaf and Vitex have been documented in our database. However, always consult a healthcare provider before combining supplements.