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Head-to-head evidence comparison — which supplement is right for you?
Resistant Starch and Saccharomyces Boulardii are closely matched across evidence, studies, and safety.
Verdict
Likely helps
17 of 19 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
13 of 15 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (2)
Outcomes where both Resistant Starch and Saccharomyces Boulardii have evidence — compare verdict strength side-by-side.
15-30g daily
With meals, Divide throughout day for higher doses
Raw potato starch (unmodified) or green banana flour
250-500mg (5-10 billion CFU) daily
With or without food, At least 2 hours away from antifungals
Capsules (lyophilized)
2-4 weeks
4-8 weeks
1-2 weeks
First 1-2 weeks
During use
1-3 days
1-2 weeks
Metabolic Effects of Resistant Starch Type 2: A Systematic Literature Review and Meta-Analysis of Randomized Controlled Trials
Nutrients (2019) · Meta analysis · n=670
However, these outcomes were heavily influenced by positive results from a small number of individual studies which contradicted the conclusions of the majority of trials.
Acute Effects of Dietary Fiber in Starchy Foods on Glycemic and Insulinemic Responses: A Systematic Review of Randomized Controlled Crossover Trials
Nutrients (2023) · Systematic review
Data on insoluble DF and glucose metabolism are scarce.
The Effects of Resistant Starch on Biomarkers of Inflammation and Oxidative Stress: A Systematic Review and Meta-Analysis
Nutrition and cancer (2022) · Meta analysis · n=739
We used from the effect size, as estimated by the standardized mean difference (SMD) with 95% confidence intervals (95%CI) to perform the random method meta-analysis, with P value ≦0.05 as statistically significant.
Efficacy and safety of Saccharomyces boulardii as an adjuvant therapy for the eradication of Helicobacter pylori: a meta-analysis
Frontiers in cellular and infection microbiology (2025) · Meta analysis · n=5036
S. boulardii supplementation in traditional eradication therapy significantly improves the H. pylori eradication rate and reduces the total adverse effects and incidence of diarrhea, bloating, constipation, and nausea.
Probiotics for treating acute infectious diarrhoea
The Cochrane database of systematic reviews (2020) · Meta analysis · n=12127
Effect size was similar in the sensitivity analysis and marked heterogeneity persisted.
The use of probiotics and prebiotics in decolonizing pathogenic bacteria from the gut; a systematic review and meta-analysis of clinical outcomes
Gut microbes (2024) · Meta analysis · n=2871
This review aims to analyze available evidence from human-controlled trials to determine the effect size of probiotic interventions in decolonizing AMR pathogenic bacteria from the gut.
Meta-analysis showed modest 3.32 mg/dL reduction in fasting glucose. Effects were heavily influenced by small number of positive studies, with majority showing mixed results. Higher doses increase GI side effects.
Based on multiple meta-analyses showing 1.1-1.6 day reduction in diarrhea duration. Effect size appears to plateau at standard therapeutic doses. Limited data on doses above 20 billion CFU.
AI-estimated from published studies. Interpret as directional guidance.
Both Resistant Starch and Saccharomyces Boulardii are closely matched — the best choice depends on your specific health goals.
For reduce inflammation, Saccharomyces Boulardii has a higher relevance score (90 vs 85).
No known interactions between Resistant Starch and Saccharomyces Boulardii have been documented in our database. However, always consult a healthcare provider before combining supplements.