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Head-to-head evidence comparison — which supplement is right for you?
Semaglutide vs Shilajit: Shilajit has the stronger overall evidence (5 vs 8.5/10); the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Shilajit wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Mostly mechanism / observational
1 of 1 studies with measurable effects showed benefit.
Top outcomes
Prescription-only, clinician-titrated. Subcutaneous (Wegovy weight management: escalate to 2.4 mg once weekly; Ozempic diabetes: 0.5-2.0 mg once weekly). Oral (Rybelsus diabetes: 3-14 mg once daily). DO NOT self-dose.
any
Subcutaneous once-weekly injection (Ozempic / Wegovy)
300-500mg purified extract
Morning, With or without food
Purified resin or PrimaVie extract
Weeks to months
Months (titrated over 16-20 weeks)
Months to years
Especially during dose escalation
2-4 weeks
8-12 weeks
2-4 weeks
Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP 1).
N Engl J Med (2021) · Rct · n=1961
Double-blind RCT in 1,961 adults with obesity/overweight WITHOUT diabetes, randomized 2:1 to subcutaneous semaglutide 2.4 mg/week or placebo plus lifestyle for 68 weeks
Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes (SELECT).
N Engl J Med (2023) · Rct · n=17604
Large cardiovascular-outcomes RCT: 17,604 patients with preexisting cardiovascular disease and overweight/obesity but WITHOUT diabetes
Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes (SUSTAIN-6).
N Engl J Med (2016) · Rct · n=3297
Pre-approval cardiovascular-safety RCT in 3,297 patients with type 2 diabetes at high cardiovascular risk, semaglutide (0.5/1.0 mg/week) vs placebo for 104 weeks
Safety and efficacy of shilajit (mumie, moomiyo)
Phytotherapy research : PTR (2014) · Review
Furthermore, animal and human data support its use as a 'revitalizer', enhancing physical performance and relieving fatigue with enhanced production of ATP.
Shilajit: a review
Phytotherapy research : PTR (2007) · Review
It has been found to consist of a complex mixture of organic humic substances and plant and microbial metabolites occurring in the rock rhizospheres of its natural habitat.
Effects of 12 Weeks of Chromium, Phyllanthus emblica Fruit Extract, and Shilajit Supplementation on Markers of Cardiometabolic Health, Fitness, and Weight Loss in Men and Women with Risk Factors to Metabolic Syndrome Initiating an Exercise and Diet Intervention: A Randomized Double-Blind, Placebo-Controlled Trial
Nutrients (2025) · Rct · n=166
Methods: In total, 166 sedentary men and women with at least two markers of metabolic syndrome participated in a randomized, placebo-controlled, parallel-arm, and repeated-measure intervention study, of which 109 completed the study (48.6 ± 10 yrs., 34.2 ± 6 kg/m2, 41.3 ± 7% fat).
Based on 20% testosterone increase in healthy volunteers at 500mg for 90 days. Conservative estimate given systematic review found most testosterone boosters fail to increase levels. Limited to purified extracts only.
AI-estimated from published studies. Interpret as directional guidance.
Shilajit has a higher evidence score (5/10 vs 8.5/10) and wins in 2 of 3 categories.
No known interactions between Semaglutide and Shilajit have been documented in our database. However, always consult a healthcare provider before combining supplements.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.