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Head-to-head evidence comparison — which supplement is right for you?
Tribulus vs Vitamin D3: Vitamin D3 has the stronger overall evidence (7.5 vs 5.5/10); they're alternatives for menopause support — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Vitamin D3 wins 3 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
3 of 3 studies with measurable effects showed benefit.
Top outcomes
Verdict
Probably helps
7 of 14 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Tribulus and Vitamin D3 have evidence — compare verdict strength side-by-side.
250-750mg daily (standardized to 45-60% saponins)
With meals, Morning or divided doses
Extract standardized to 45-60% saponins (protodioscin)
2000-4000 IU daily
Morning with breakfast
D3 (cholecalciferol) softgel or liquid
and 1 more not shown
2-4 weeks
4-8 weeks
N/A
4-8 weeks
4-8 weeks
2-4 weeks
4-8 weeks
Effects of Tribulus (Tribulus terrestris L.) Supplementation on Erectile Dysfunction and Testosterone Levels in Men-A Systematic Review of Clinical Trials
Nutrients (2025) · Systematic review · n=483
10 studies (9 clinical trials and 1 study without a control) with 483 men in total, aged 16 to 70.
Dietary Supplements for Erectile Dysfunction: Analysis of Marketed Products, Systematic Review, Meta-Analysis and Rational Use
Nutrients (2023) · Meta analysis
Based on the scoring system, 2 (8%) supplements matched with the cluster of higher expected efficacy, 3 (12%) with the lower efficacy cluster and 20 (80%) matched with the criterion of no expected efficacy.
Beneficial effects of natural products on female sexual dysfunction: A systematic review and meta-analysis
Phytomedicine : international journal of phytotherapy and phytopharmacology (2021) · Meta analysis
536 studies were identified and 20 met the criteria. The abstract gives no participant total.
Vitamin D supplementation vs. placebo and incident type 2 diabetes in an ancillary study of the randomized Vitamin D and Omega-3 Trial
Nature communications (2025) · Rct · n=22220
Ancillary analysis of VITAL: 22,220 adults without T2D randomized to vitamin D3 2000 IU/day or placebo, with a meta-analysis of 3 additional trials.
Vitamin D Supplementation for Patients with Dysmenorrhoea: A Meta-Analysis with Trial Sequential Analysis of Randomised Controlled Trials
Nutrients (2024) · Meta analysis · n=687
TSA revealed that the current RCTs provide sufficient information.
Vitamin D and respiratory tract infections
BMJ (2017) · Meta analysis · n=11321
25 RCTs, 11 321 participants aged 0 to 95 years. Vitamin D reduced acute respiratory tract infection overall (adjusted OR 0.88, 95% CI 0.81 to 0.96).
Both points come from a meta-analysis of double-blind cholecalciferol trials in people aged 60 and over (PMID 15886381). Trials at 700 to 800 IU a day cut hip fracture risk by 26% (RR 0.74) and non-vertebral fractures by 23%, plotted at 800 IU. Trials at 400 IU a day showed no benefit (hip fracture RR 1.15), and the WHI trial of 400 IU with 1,000 mg calcium did not significantly reduce hip fracture (PMID 16481635). Most of these trials also gave calcium, and the Cochrane review found vitamin D alone unlikely to prevent fractures while vitamin D with calcium gave a small reduction (PMID 24729336). Doses above 800 IU were not compared, so no optimal dose or ceiling is set.
AI-estimated from published studies. Interpret as directional guidance.
Vitamin D3 has a higher evidence score (7.5/10 vs 5.5/10) and wins in 3 of 3 categories.
For menopause support, Vitamin D3 has a higher relevance score (90 vs 15).
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
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The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.