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Head-to-head evidence comparison — which supplement is right for you?
Caffeine and Tribulus are closely matched across evidence, studies, and safety.
Verdict
Likely helps
22 of 25 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
4 of 4 studies with measurable effects showed benefit.
Top outcomes
100-200mg
Morning, 30-60 minutes before exercise
Pill/capsule for precise dosing
250-750mg daily (standardized to 45-60% saponins)
With meals, Morning or divided doses
Extract standardized to 45-60% saponins (protodioscin)
15-45 minutes
30-60 minutes
30-60 minutes
30-60 minutes
2-4 weeks
4-8 weeks
N/A
Effect of Acute Caffeine Intake on the Fat Oxidation Rate during Exercise: A Systematic Review and Meta-Analysis
Nutrients (2020) · Meta analysis · n=2020
A subsequent meta-analysis was performed using the random effects model to calculate the standardized mean difference (SMD).
The effects of caffeine intake on weight loss: a systematic review and dos-response meta-analysis of randomized controlled trials
Critical reviews in food science and nutrition (2019) · Meta analysis · n=606
Thirteen RCTs with 606 participants were included in the meta-analyses.
Effect of Caffeine and Nitrates Combination on Exercise Performance, Heart Rate and Oxygen Uptake: A Systematic Review and Meta-Analysis
Nutrients (2024) · Meta analysis · n=95
The meta-analysis revealed that caffeine and nitrates supplementation (CAF+nitrates) did not enhance performance in time trials (TTs) over the CAF alone (g = -0.06; 95% CI = -0.46 to 0.35; p = 0.78) or nitrates alone (g = 0.29; 95% CI = -0.12 to 0.70; p = 0.17).
Effects of Tribulus (Tribulus terrestris L.) Supplementation on Erectile Dysfunction and Testosterone Levels in Men-A Systematic Review of Clinical Trials
Nutrients (2025) · Systematic review · n=172
The Jadad score revealed low methodological quality for 50% of the studies.
Dietary Supplements for Erectile Dysfunction: Analysis of Marketed Products, Systematic Review, Meta-Analysis and Rational Use
Nutrients (2023) · Meta analysis
Based on the scoring system, 2 (8%) supplements matched with the cluster of higher expected efficacy, 3 (12%) with the lower efficacy cluster and 20 (80%) matched with the criterion of no expected efficacy.
Beneficial effects of natural products on female sexual dysfunction: A systematic review and meta-analysis
Phytomedicine : international journal of phytotherapy and phytopharmacology (2021) · Meta analysis · n=536
Panax ginseng was found to be effective in treating sexual arousal (SMD = 0.54, 95% CI = 0.11 - 0.97, p = 0.014) and sexual desire (SMD = 0.59, 95% CI = 0.27 - 0.90, p < 0.001) compared to placebo.
Based on multiple meta-analyses showing 3-6mg/kg optimal dosing. Performance benefits plateau around 200-300mg with increased jitteriness at higher doses.
Based on systematic review showing improvement in 3 of 5 studies at 400-750mg doses. Studies had low methodological quality (50% low Jadad scores). Effects primarily in men with existing ED.
AI-estimated from published studies. Interpret as directional guidance.
Both Caffeine and Tribulus are closely matched — the best choice depends on your specific health goals.
For boost daily energy, Caffeine has a higher relevance score (98 vs 42).
No known interactions between Caffeine and Tribulus have been documented in our database. However, always consult a healthcare provider before combining supplements.