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Head-to-head evidence comparison — which supplement is right for you?
Vitamin E vs Vitamin K1: Vitamin E has the stronger overall evidence (5 vs 4/10); they work on different things and are often used together, not either/or. Take the 60-second quiz for a pick tailored to your goals.
Vitamin E wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
10 of 10 studies with measurable effects showed benefit.
Top outcomes
Verdict
Too few graded studies
Top outcomes
Shared outcomes (1)
Outcomes where both Vitamin E and Vitamin K1 have evidence — compare verdict strength side-by-side.
No routine vitamin E supplement dose is recommended here for longevity. Use a product-specific dose only for a defined indication under an agreed clinical plan, taking account of the exact form and all sources.
With fat-containing meal, Any time of day
No form is preferred here for routine longevity use. For a defined clinical indication, select the exact product and alpha-tocopherol form specified in the agreed plan.
Dietary adequacy ~90-120mcg/day; supplements often 100-500mcg (a typical label dose, not the dose used in the cited trial, which used 1,000 mcg a day)
With meals
Phylloquinone (K1)
Potential interaction under clinical review.
Not graded yet, under clinical review. Precaution meanwhile: Taking one is not, on its own, a reason to stop ordinary nutritional amounts of the other. Have a clinician review high-dose vitamin E first, especially with an anticoagulant, bleeding risk or an unclear supplement regimen. No dose has been established as safe for everyone, and a few hours apart has not been shown to protect. Do not stop prescribed vitamin K or anticoagulant treatment because of this.
4-8 weeks
4-8 weeks
8-12 weeks
With high doses
Days
6-12 months
Effect of vitamin B(2), vitamin C, vitamin D, vitamin E and folic acid in adults with essential hypertension: a systematic review and network meta-analysis
BMJ open (2024) · Meta analysis · n=2218
Among the five vitamins, only vitamin E was significantly more effective at reducing SBP (mean difference: -14.14 mm Hg, 95% credible intervals: -27.62 to -0.88) than placebo.
The Effect of Vitamin E Supplementation on Serum Aminotransferases in Non-Alcoholic Fatty Liver Disease (NAFLD): A Systematic Review and Meta-Analysis
Nutrients (2023) · Meta analysis · n=794
A total of 794 patients from 12 randomized trials were included in this meta-analysis.
Vitamin E supplementation in pregnancy
The Cochrane database of systematic reviews (2015) · Meta analysis · n=22129
Twenty-one trials, involving 22,129 women were eligible for this review. All of the 17 trials contributing data assessed vitamin E in combination with vitamin C and/or other agents.
The additive effect of vitamin K supplementation and bisphosphonate on fracture risk in post-menopausal osteoporosis: a randomised placebo controlled trial.
Arch Osteoporos (2023) · Rct · n=35
NO significant effect on bone density (BMD) or bone-turnover markers vs placebo
Vitamin K.
(2006) · Review
Reviews vitamin K in breast milk and maternal supplementation during lactation
Vitamin K and osteoporosis: Myth or reality?
Metabolism: clinical and experimental (2017) · Systematic review
Systematic review of vitamin K (K1/K2) and osteoporosis / bone health
Vitamin E has a higher evidence score (5/10 vs 4/10) and wins in 2 of 3 categories.
Not graded yet, under clinical review. Precaution meanwhile: Taking one is not, on its own, a reason to stop ordinary nutritional amounts of the other. Have a clinician review high-dose vitamin E first, especially with an anticoagulant, bleeding risk or an unclear supplement regimen. No dose has been established as safe for everyone, and a few hours apart has not been shown to protect. Do not stop prescribed vitamin K or anticoagulant treatment because of this.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.