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A-F grade per outcome, combining overall evidence with goal-specific relevance. A = strong evidence; F = insufficient. Hover a badge for details.
Direct side-by-side from the meta-analysis. Each row is an outcome where ≥2 of your selected supplements have pooled data. Best effect per row highlighted.
| Outcome | Niacin | SAMe |
|---|---|---|
| Support mood — Depression − better · points (PHQ-9) | −8.6best moderate | −4.9 moderate |
1500mg
With meals · with food
Immediate-release niacin (nicotinic acid)
1000mg
Morning
Enteric-coated tablets (SAMe tosylate or butanedisulfonate)
4-8 weeks
4-8 weeks
30-60 minutes after dose
2-6 weeks
4-8 weeks
4-8 weeks
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