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Vitamin E und Vitamin K2 können wechselwirken. Vitamin E at supplement doses measurably lowered vitamin K status in adults with normal clotting. Menaquinone is taken to carboxylate osteocalcin and matrix Gla protein — the very reaction high-dose vitamin E impairs — so the two work against each other. Keep vitamin E at or below 400 IU/day if you are also taking K2, and separate them by a few hours to reduce absorption competition. Do not use this pairing to self-manage clotting: if you are on an anticoagulant, both belong in a conversation with the prescriber.
Vitamin E at supplement doses measurably lowered vitamin K status in adults with normal clotting. Menaquinone is taken to carboxylate osteocalcin and matrix Gla protein — the very reaction high-dose vitamin E impairs — so the two work against each other.
High-dose alpha-tocopherol interferes with vitamin K-dependent gamma-carboxylation, and its quinone metabolite competes with vitamin K in that pathway. The two are also fat-soluble vitamins competing for the same absorption route.
Was zu tun ist: Keep vitamin E at or below 400 IU/day if you are also taking K2, and separate them by a few hours to reduce absorption competition. Do not use this pairing to self-manage clotting: if you are on an anticoagulant, both belong in a conversation with the prescriber.
Die Dosis ist entscheidend: >400 IU/day vitamin E. Minimal risk: <200 IU/day vitamin E.
This information is for educational purposes only. Sie ersetzt keine professionelle medizinische Beratung. Sprich immer mit einer qualifizierten medizinischen Fachperson, bevor du ein Supplement oder Medikament beginnst, absetzt oder änderst.