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Calcium and Silicon can be taken together. Any benefit from combining them rests on limited evidence. Silica (5–20 mg orthosilicic acid equivalent/day) can be taken with calcium. A bone-density benefit has not been shown.
In a 12-month RCT of 136 women with low bone density, all taking calcium and vitamin D3, added orthosilicic acid raised one bone-formation marker (PINP) but did not change spine bone density.
Silicon/silica promotes the synthesis of collagen type I and activates osteoblastic activity, providing the organic matrix scaffold upon which calcium (hydroxyapatite) is deposited. Silicon also influences calcium and phosphorus incorporation into bone by stimulating osteoblast differentiation via insulin-like growth factor-1 signaling.
What to do: Silica (5–20 mg orthosilicic acid equivalent/day) can be taken with calcium. A bone-density benefit has not been shown.
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.