St. John's Wort and Vitamin D3: Can You Take Them Together?

Notable interaction — adjust timing

St. John's Wort and Vitamin D3 can interact. May reduce vitamin D effectiveness and serum 25(OH)D levels Monitor vitamin D status if using St. Johns Wort long-term.

What the evidence says

moderateconflict· moderate evidence

May reduce vitamin D effectiveness and serum 25(OH)D levels

St. Johns Wort induces CYP3A4, increasing vitamin D metabolism

What to do: Monitor vitamin D status if using St. Johns Wort long-term.

St. John's Wort

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Vitamin D3

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Compare St. John's Wort vs Vitamin D3 Check your full stack

Related interactions

Calcium & Vitamin D3 Vitamin D3 & Vitamin K2 Magnesium & Vitamin D3 Vitamin A & Vitamin D3 Vitamin D3 & Vitamin E Multivitamin & Vitamin D3

Frequently asked questions

Can you take St. John's Wort and Vitamin D3 together?: St. John's Wort and Vitamin D3 can interact. May reduce vitamin D effectiveness and serum 25(OH)D levels Monitor vitamin D status if using St. Johns Wort long-term.
Do St. John's Wort and Vitamin D3 interact?: May reduce vitamin D effectiveness and serum 25(OH)D levels St. Johns Wort induces CYP3A4, increasing vitamin D metabolism
Should you separate St. John's Wort and Vitamin D3?: Monitor vitamin D status if using St. Johns Wort long-term.

This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.