Matt Kaeberlein — foundations-first minimalist regimen

The biogerontologist’s deliberately short list — he stresses exercise/sleep/nutrition deliver the vast majority of benefit and supplements only "incremental" gains, dosing only to correct a measured deficiency. He takes NO NAD precursor. Note: the widely-circulated "stopped rapamycin after side effects" story is Bryan Johnson’s — Kaeberlein continues cycling it. Documented, not endorsed.

Matt Kaeberlein is an American biologist and biogerontologist best known for his research on evolutionarily conserved mechanisms of aging . He is currently a professor of pathology at the University of Washington in Seattle.

Website ↗Wikipedia ↗

Photo: MatthewGorelik1 / CC BY-SA 4.0, via Wikimedia Commons

Documented, not endorsed. What Matt Kaeberlein, PhD reports taking (as of 2026-06) — not medical advice, not a recommendation. We sell nothing; each item links to its independently evidence-graded card.

At a glance

Aimed at (inferred from 9 mapped members)

🧬 Longevity & healthspan 4😌 Mood & stress 4💪 Performance & recovery 3🩺 General health 2🧠 Cognition 2

Evidence makeup

3 Strong 3 Moderate 2 Emerging 1 Gated / research compound

1 of 9 mapped items are gated research compounds — informational only.

The stack · 9 compounds

Core

⏳ Rapamycinresearch compound
Cycled; animal data — he continues it and explicitly pushes back on influencers who quit.
Emerging 4.5~6 mg weekly × ~12 wks, then a long break
☀️ Vitamin D3
Corrects a deficiency.
Moderate 7.5no dose info (for a measured deficiency)
🔴 Vitamin B12
Corrects a deficiency.
Moderate 7.5no dose info (for a measured deficiency)
🐟 Omega-3
Corrects a deficiency.
Strong 9.0no dose info (for a measured deficiency)
⚡ Creatine
Muscle maintenance; emerging cognitive interest.
Strong 9.5~5 g

Situational

✨ Magnesium
General supplementation.
Strong 8.5no dose info
✨ Collagen
Joint/skin.
Moderate 6.0in morning shake
⚗️ Lithium Orotate
Lower-confidence recent addition (dementia-epidemiology rationale).
Emerging 2.2~5 mg (recent)
⚗️ Calcium AKG
Lower-confidence recent addition.
Emerging 3.5no dose info (Rejuvant)

“no dose info” = publicly known to take it, but no reliable dose has been stated.

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“Start” adds the 8 evidence-graded compounds to your own stack to edit — gated research compounds excluded. Not an endorsement.

Synergies (1)

Vitamin D3 + Magnesium — Magnesium deficiency impairs vitamin D metabolism and effectiveness

Documented supplement–supplement interactions between members of this stack — not a personal interaction check. Full interaction checker →

Compare with another stack

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Sources: Optispan podcast / interviews